ID   HVR01_RAT               Reviewed;         142 AA.
AC   P01805;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Ig heavy chain V region IR2;
DE   Flags: Precursor;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=6292865; DOI=10.1093/nar/10.19.6041;
RA   Hellman L., Pettersson U., Engstroem A., Karlsson T., Bennich H.;
RT   "Structure and evolution of the heavy chain from rat immunoglobulin E.";
RL   Nucleic Acids Res. 10:6041-6049(1982).
CC   -!- MISCELLANEOUS: The mRNA was isolated from an IgE-secreting immunocytoma
CC       that arises spontaneously in LOU/C/WsL rats.
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DR   PIR; A02075; EVRTR2.
DR   AlphaFoldDB; P01805; -.
DR   SMR; P01805; -.
DR   STRING; 10116.ENSRNOP00000067650; -.
DR   PRIDE; P01805; -.
DR   eggNOG; ENOG502S5S3; Eukaryota.
DR   PhylomeDB; P01805; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR   GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR   GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR   GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR   GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR   GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   4: Predicted;
KW   Adaptive immunity; Immunity; Immunoglobulin; Reference proteome; Signal.
FT   SIGNAL          1..19
FT   CHAIN           20..142
FT                   /note="Ig heavy chain V region IR2"
FT                   /id="PRO_0000015215"
FT   DOMAIN          20..133
FT                   /note="Ig-like"
FT   NON_TER         142
SQ   SEQUENCE   142 AA;  16024 MW;  DE29E6CFE745DF3B CRC64;
     MDLRLTYVFI VAILKGVLCE VKLEESGGGL VQPGMSVKLS CATSGFTFSD YWMEWVRQAP
     GKGLEWVAEI RNKANNYVAY YGKSLKGRFT LSRDDSKSIV YLQMNNIRSE DTGIYYCSRG
     YGGYSENWFV YWGQGTLVTV SS