ID   HVRA_RHOCA              Reviewed;         102 AA.
AC   P42505;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Trans-acting regulatory protein HvrA;
GN   Name=hvrA;
OS   Rhodobacter capsulatus (Rhodopseudomonas capsulata).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Rhodobacter.
OX   NCBI_TaxID=1061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION, AND DISRUPTION
RP   PHENOTYPE.
RC   STRAIN=ATCC 23782 / St Louis;
RX   PubMed=7961455; DOI=10.1128/jb.176.22.6936-6943.1994;
RA   Buggy J.J., Sganga M.W., Bauer C.E.;
RT   "Characterization of a light-responding trans-activator responsible for
RT   differentially controlling reaction center and light-harvesting-I gene
RT   expression in Rhodobacter capsulatus.";
RL   J. Bacteriol. 176:6936-6943(1994).
CC   -!- FUNCTION: A dim-light trans-acting activator of Puf and Puh expression,
CC       that has no effect on the expression of the Puc operon. Responsible for
CC       regulating light-harvesting-I and reaction center structural gene
CC       expression differentially from that of light-harvesting-II expression
CC       in response to alterations in light. Proper light regulation of light-
CC       harvesting and reaction center polypeptide synthesis is an important
CC       physiological trait that enables cells to adapt to ever-changing
CC       environmental conditions of light intensity.
CC       {ECO:0000269|PubMed:7961455}.
CC   -!- SUBUNIT: Homodimer that oligomerizes on DNA into higher-order complexes
CC       that form bridges between disparate regions of DNA compacting it (By
CC       similarity). {ECO:0000250|UniProtKB:P0ACF8}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid
CC       {ECO:0000250|UniProtKB:P0ACF8}.
CC   -!- INDUCTION: Expressed in light-grown cells, probably a member of the
CC       senC-regA-hvrA operon (PubMed:7961455). {ECO:0000269|PubMed:7961455}.
CC   -!- DISRUPTION PHENOTYPE: Grows normally under saturating light (6000 lux),
CC       in low light (80 lux) grows poorly, decreased induction of puf and puh
CC       but not puc operons nor genes for bacteriochlorophyll biosynthesis
CC       (PubMed:7961455). {ECO:0000269|PubMed:7961455}.
CC   -!- SIMILARITY: Belongs to the histone-like protein H-NS family.
CC       {ECO:0000305}.
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DR   EMBL; X67236; CAA47662.1; -; Genomic_DNA.
DR   RefSeq; WP_013065793.1; NZ_VIBE01000003.1.
DR   AlphaFoldDB; P42505; -.
DR   SMR; P42505; -.
DR   GeneID; 31489003; -.
DR   OMA; WIKEWLE; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 4.10.430.10; -; 1.
DR   InterPro; IPR027444; H-NS_C_dom.
DR   InterPro; IPR037150; H-NS_C_dom_sf.
DR   InterPro; IPR001801; Histone_HNS.
DR   Pfam; PF00816; Histone_HNS; 1.
DR   SMART; SM00528; HNS; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cytoplasm; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..102
FT                   /note="Trans-acting regulatory protein HvrA"
FT                   /id="PRO_0000168518"
FT   DNA_BIND        80..85
FT                   /evidence="ECO:0000250|UniProtKB:P0A1S2"
SQ   SEQUENCE   102 AA;  11435 MW;  0F058BEB9D6D0F71 CRC64;
     MDIDALSLNE LKALRSKVDR AIVTYEERKK KEAFAELDEI ARKMGYPLAE ILTMVETKPR
     KTVAAKYANP ANPSETWTGR GRKPKWVEAA LASGKSLEDL TI