ID   HVTJ_LACHE              Reviewed;         333 AA.
AC   P22294;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Bacteriocin helveticin-J;
GN   Name=hlv;
OS   Lactobacillus helveticus (Lactobacillus suntoryeus).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=1587;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=481;
RX   PubMed=2228964; DOI=10.1128/jb.172.11.6339-6347.1990;
RA   Joerger M.C., Klaenhammer T.R.;
RT   "Cloning, expression, and nucleotide sequence of the Lactobacillus
RT   helveticus 481 gene encoding the bacteriocin helveticin J.";
RL   J. Bacteriol. 172:6339-6347(1990).
CC   -!- FUNCTION: This heat-sensitive bacteriocin inhibits the growth of
CC       closely related Lactobacillus species.
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DR   EMBL; M59360; AAA63274.1; -; Genomic_DNA.
DR   PIR; C37145; C37145.
DR   RefSeq; WP_025006474.1; NZ_QJOJ01000041.1.
DR   AlphaFoldDB; P22294; -.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR035280; Helveticin_J.
DR   Pfam; PF17312; Helveticin_J; 1.
PE   4: Predicted;
KW   Antibiotic; Antimicrobial; Bacteriocin.
FT   CHAIN           1..333
FT                   /note="Bacteriocin helveticin-J"
FT                   /id="PRO_0000110580"
SQ   SEQUENCE   333 AA;  37512 MW;  D7CE335BBB96D74F CRC64;
     MKHLNETTNV RILSQFDMDT GYQAVVQKGN VGSKYVYGLQ LRKGATTILR GYRGSKINNP
     ILELSGQAGG HTQTWEFAGD RKDINGEERA GQWFIGVKPS KIEGSKIIWA KQIARVDLRN
     QMGPHYSNTD FPRLSYLNRA GSNPFAGNKM THAEAAVSPD YTKFLIATVE NNCIGHFTIY
     NLDTINEKLD EKGNSEDVNL ETVKYEDSFI IDNLYGDDNN SIVNSIQGYD LDNDGNIYIS
     SQKAPDFDGS YYAHHKQIVK IPYYARSKES EDQWRAVNLS EFGGLDIPGK HSEVESIQII
     GENHCYLTVA YHSKNKAGEN KTTLNEIYEL SWN