HXA10_HETFR
ID HXA10_HETFR Reviewed; 271 AA.
AC Q9IA27;
DT 11-JUL-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Homeobox protein Hox-A10;
GN Name=HOXA10;
OS Heterodontus francisci (Horn shark) (Cestracion francisci).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Heterodontoidea; Heterodontiformes;
OC Heterodontidae; Heterodontus.
OX NCBI_TaxID=7792;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10677514; DOI=10.1073/pnas.030539697;
RA Kim C.B., Amemiya C., Bailey W., Kawasaki K., Mezey J., Miller W.,
RA Minoshima S., Shimizu N., Wagner G., Ruddle F.;
RT "Hox cluster genomics in the horn shark, Heterodontus francisci.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:1655-1660(2000).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR EMBL; AF224262; AAF44647.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9IA27; -.
DR SMR; Q9IA27; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR046333; HXA10/ABDB-like.
DR PANTHER; PTHR45874; PTHR45874; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW Transcription regulation.
FT CHAIN 1..271
FT /note="Homeobox protein Hox-A10"
FT /id="PRO_0000200093"
FT DNA_BIND 197..256
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 61..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 109..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 271 AA; 30232 MW; 4F732F4B0D1D0A71 CRC64;
MSGMEVWSDP PRSCRMEQPA TQQVATCSFP QNIKEENAYC LYDSEKCPKS AAATDLSTFP
RLTSESCSNN DTTTSGGVPV PGYFRLSQAY PTSKQTLYSN TGQVGASPFV PQSQIRFGTP
PSSASTPTEL GRKGSEGTSP GHLTCSSERE EAEAAASSAN EESSPVPSES NKNSPEKETK
GEVKAENGAN WLTAKSGRKK RCPYTKHQTL ELEKEFLFNM YLTRERRLEI SRSVHLTDRQ
VKIWFQNRRM KLKKMNRENR IRELTANFSF S