HXA10_HUMAN
ID HXA10_HUMAN Reviewed; 410 AA.
AC P31260; O43370; O43605; Q15949; Q504T1;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 3.
DT 03-AUG-2022, entry version 209.
DE RecName: Full=Homeobox protein Hox-A10;
DE AltName: Full=Homeobox protein Hox-1.8;
DE AltName: Full=Homeobox protein Hox-1H;
DE AltName: Full=PL;
GN Name=HOXA10; Synonyms=HOX1H;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING.
RX PubMed=1676505; DOI=10.1093/nar/19.12.3443;
RA Lowney P., Corral J.C., Detmer K., Lebeau M.M., Deaven L., Lawrence H.J.,
RA Largman C.;
RT "A human Hox 1 homeobox gene exhibits myeloid-specific expression of
RT alternative transcripts in human hematopoietic cells.";
RL Nucleic Acids Res. 19:3443-3449(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Mi X., Winters J.L., Stevens D.B., Fleischman R.A.;
RL Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Caudate nucleus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 2-410 (ISOFORM 1).
RC TISSUE=Muscle, and Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 318-400.
RX PubMed=2573064; DOI=10.1073/pnas.86.21.8536;
RA Shen W.-F., Largman C., Lowney P., Corral J.C., Detmer K., Hauser C.A.,
RA Simonitch T.A., Hack F.M., Lawrence H.J.;
RT "Lineage-restricted expression of homeobox-containing genes in human
RT hematopoietic cell lines.";
RL Proc. Natl. Acad. Sci. U.S.A. 86:8536-8540(1989).
RN [8]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 336-396.
RX PubMed=2574852; DOI=10.1093/nar/17.24.10385;
RA Acampora D., D'Esposito M., Faiella A., Pannese M., Migliaccio E.,
RA Morelli F., Stornaiuolo A., Nigro V., Simeone A., Boncinelli E.;
RT "The human HOX gene family.";
RL Nucleic Acids Res. 17:10385-10402(1989).
RN [9]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 349-387.
RX PubMed=7906121; DOI=10.1016/0006-2952(94)90447-2;
RA Castronovo V., Kusaka M., Chariot A., Gielen J., Sobel M.;
RT "Homeobox genes: potential candidates for the transcriptional control of
RT the transformed and invasive phenotype.";
RL Biochem. Pharmacol. 47:137-143(1994).
RN [10]
RP INTERACTION WITH SIRT2.
RX PubMed=15213244; DOI=10.1093/jb/mvh084;
RA Bae N.S., Swanson M.J., Vassilev A., Howard B.H.;
RT "Human histone deacetylase SIRT2 interacts with the homeobox transcription
RT factor HOXA10.";
RL J. Biochem. 135:695-700(2004).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. Binds to the DNA
CC sequence 5'-AA[AT]TTTTATTAC-3'.
CC -!- SUBUNIT: Interacts with SIRT2; the interaction is direct.
CC {ECO:0000269|PubMed:15213244}.
CC -!- INTERACTION:
CC P31260; P17947: SPI1; NbExp=2; IntAct=EBI-2293516, EBI-2293548;
CC P31260-2; Q9P2W3: GNG13; NbExp=3; IntAct=EBI-12896693, EBI-11427343;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=PL1;
CC IsoId=P31260-1; Sequence=Displayed;
CC Name=2; Synonyms=PL2;
CC IsoId=P31260-2; Sequence=VSP_002384, VSP_002385;
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB96917.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH13971.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAB86198.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; X58430; CAB86198.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AF040714; AAB96917.1; ALT_INIT; Genomic_DNA.
DR EMBL; AK312450; BAG35357.1; -; mRNA.
DR EMBL; AC004080; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471073; EAW93885.1; -; Genomic_DNA.
DR EMBL; BC013971; AAH13971.1; ALT_INIT; mRNA.
DR EMBL; BC071843; AAH71843.1; -; mRNA.
DR EMBL; BC094807; AAH94807.1; -; mRNA.
DR EMBL; M30599; AAA36006.1; -; mRNA.
DR EMBL; S69027; AAD14030.1; -; mRNA.
DR EMBL; S69029; AAD14031.1; -; mRNA.
DR CCDS; CCDS5410.2; -. [P31260-1]
DR PIR; I65264; I65264.
DR PIR; I65265; I65265.
DR PIR; S26402; S26402.
DR PIR; S28814; S28814.
DR RefSeq; NP_061824.3; NM_018951.3. [P31260-1]
DR AlphaFoldDB; P31260; -.
DR SMR; P31260; -.
DR BioGRID; 109446; 33.
DR IntAct; P31260; 16.
DR MINT; P31260; -.
DR STRING; 9606.ENSP00000283921; -.
DR DrugBank; DB00136; Calcitriol.
DR iPTMnet; P31260; -.
DR PhosphoSitePlus; P31260; -.
DR BioMuta; HOXA10; -.
DR DMDM; 294862509; -.
DR jPOST; P31260; -.
DR MassIVE; P31260; -.
DR MaxQB; P31260; -.
DR PaxDb; P31260; -.
DR PeptideAtlas; P31260; -.
DR PRIDE; P31260; -.
DR ProteomicsDB; 54766; -. [P31260-1]
DR ProteomicsDB; 54767; -. [P31260-2]
DR Antibodypedia; 48441; 224 antibodies from 26 providers.
DR DNASU; 3206; -.
DR Ensembl; ENST00000283921.5; ENSP00000283921.4; ENSG00000253293.6. [P31260-1]
DR Ensembl; ENST00000396344.4; ENSP00000379633.4; ENSG00000253293.6. [P31260-2]
DR GeneID; 3206; -.
DR KEGG; hsa:3206; -.
DR MANE-Select; ENST00000283921.5; ENSP00000283921.4; NM_018951.4; NP_061824.3.
DR UCSC; uc011jzm.3; human. [P31260-1]
DR CTD; 3206; -.
DR DisGeNET; 3206; -.
DR GeneCards; HOXA10; -.
DR HGNC; HGNC:5100; HOXA10.
DR HPA; ENSG00000253293; Tissue enhanced (endometrium, skeletal muscle).
DR MIM; 142957; gene.
DR neXtProt; NX_P31260; -.
DR OpenTargets; ENSG00000253293; -.
DR PharmGKB; PA29377; -.
DR VEuPathDB; HostDB:ENSG00000253293; -.
DR eggNOG; KOG0487; Eukaryota.
DR GeneTree; ENSGT00940000162440; -.
DR HOGENOM; CLU_057871_0_0_1; -.
DR InParanoid; P31260; -.
DR OMA; YDSEKCP; -.
DR OrthoDB; 976319at2759; -.
DR PhylomeDB; P31260; -.
DR TreeFam; TF317819; -.
DR PathwayCommons; P31260; -.
DR SignaLink; P31260; -.
DR SIGNOR; P31260; -.
DR BioGRID-ORCS; 3206; 18 hits in 1094 CRISPR screens.
DR GeneWiki; Homeobox_A10; -.
DR GenomeRNAi; 3206; -.
DR Pharos; P31260; Tbio.
DR PRO; PR:P31260; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; P31260; protein.
DR Bgee; ENSG00000253293; Expressed in biceps brachii and 144 other tissues.
DR ExpressionAtlas; P31260; baseline and differential.
DR Genevisible; P31260; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0042826; F:histone deacetylase binding; IPI:UniProtKB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
DR GO; GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
DR GO; GO:0008584; P:male gonad development; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0030850; P:prostate gland development; IEA:Ensembl.
DR GO; GO:0009954; P:proximal/distal pattern formation; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0043627; P:response to estrogen; IEA:Ensembl.
DR GO; GO:0033574; P:response to testosterone; IEA:Ensembl.
DR GO; GO:0007338; P:single fertilization; IEA:Ensembl.
DR GO; GO:0001501; P:skeletal system development; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; TAS:ProtInc.
DR GO; GO:0060065; P:uterus development; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR046333; HXA10/ABDB-like.
DR PANTHER; PTHR45874; PTHR45874; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Developmental protein; DNA-binding; Homeobox;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..410
FT /note="Homeobox protein Hox-A10"
FT /id="PRO_0000200090"
FT DNA_BIND 336..395
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 89..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..152
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..316
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_002384"
FT VAR_SEQ 317..319
FT /note="DSL -> MCQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_002385"
FT CONFLICT 20
FT /note="C -> S (in Ref. 1; CAB86198)"
FT /evidence="ECO:0000305"
FT CONFLICT 75
FT /note="L -> W (in Ref. 1; CAB86198)"
FT /evidence="ECO:0000305"
FT CONFLICT 86
FT /note="G -> R (in Ref. 1; CAB86198)"
FT /evidence="ECO:0000305"
FT CONFLICT 153..154
FT /note="QA -> HR (in Ref. 1; CAB86198)"
FT /evidence="ECO:0000305"
FT CONFLICT 192
FT /note="P -> R (in Ref. 1; CAB86198)"
FT /evidence="ECO:0000305"
FT CONFLICT 216
FT /note="L -> P (in Ref. 1; CAB86198)"
FT /evidence="ECO:0000305"
FT CONFLICT 221
FT /note="G -> A (in Ref. 1; CAB86198)"
FT /evidence="ECO:0000305"
FT CONFLICT 231
FT /note="G -> C (in Ref. 1; CAB86198)"
FT /evidence="ECO:0000305"
FT CONFLICT 234..235
FT /note="QQ -> HE (in Ref. 1; CAB86198)"
FT /evidence="ECO:0000305"
FT CONFLICT 241
FT /note="F -> V (in Ref. 1; CAB86198)"
FT /evidence="ECO:0000305"
FT CONFLICT 248
FT /note="R -> G (in Ref. 1; CAB86198)"
FT /evidence="ECO:0000305"
FT CONFLICT 260..261
FT /note="SA -> GS (in Ref. 1; CAB86198)"
FT /evidence="ECO:0000305"
FT CONFLICT 292
FT /note="A -> G (in Ref. 1; CAB86198)"
FT /evidence="ECO:0000305"
FT CONFLICT 295
FT /note="S -> R (in Ref. 1; CAB86198)"
FT /evidence="ECO:0000305"
FT CONFLICT 349
FT /note="L -> S (in Ref. 9; AAD14031)"
FT /evidence="ECO:0000305"
FT CONFLICT 351
FT /note="L -> F (in Ref. 9; AAD14031)"
FT /evidence="ECO:0000305"
FT CONFLICT 356
FT /note="L -> H (in Ref. 9; AAD14030)"
FT /evidence="ECO:0000305"
FT CONFLICT 359
FT /note="M -> R (in Ref. 9; AAD14030)"
FT /evidence="ECO:0000305"
FT CONFLICT 364
FT /note="E -> R (in Ref. 9; AAD14030)"
FT /evidence="ECO:0000305"
FT CONFLICT 367
FT /note="L -> I (in Ref. 9; AAD14030)"
FT /evidence="ECO:0000305"
FT CONFLICT 370..374
FT /note="SRSVH -> ANALC (in Ref. 9; AAD14030)"
FT /evidence="ECO:0000305"
FT CONFLICT 377
FT /note="D -> E (in Ref. 9; AAD14030)"
FT /evidence="ECO:0000305"
FT CONFLICT 380
FT /note="V -> S (in Ref. 9; AAD14030)"
FT /evidence="ECO:0000305"
FT CONFLICT 387
FT /note="R -> P (in Ref. 9; AAD14030/AAD14031)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 410 AA; 42414 MW; E9544C35145FE7A4 CRC64;
MSARKGYLLP SPNYPTTMSC SESPAANSFL VDSLISSGRG EAGGGGGGAG GGGGGGYYAH
GGVYLPPAAD LPYGLQSCGL FPTLGGKRNE AASPGSGGGG GGLGPGAHGY GPSPIDLWLD
APRSCRMEPP DGPPPPPQQQ PPPPPQPPQP APQATSCSFA QNIKEESSYC LYDSADKCPK
VSATAAELAP FPRGPPPDGC ALGTSSGVPV PGYFRLSQAY GTAKGYGSGG GGAQQLGAGP
FPAQPPGRGF DLPPALASGS ADAARKERAL DSPPPPTLAC GSGGGSQGDE EAHASSSAAE
ELSPAPSESS KASPEKDSLG NSKGENAANW LTAKSGRKKR CPYTKHQTLE LEKEFLFNMY
LTRERRLEIS RSVHLTDRQV KIWFQNRRMK LKKMNRENRI RELTANFNFS
