HXA10_MOUSE
ID HXA10_MOUSE Reviewed; 416 AA.
AC P31310; Q80Y22;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 4.
DT 03-AUG-2022, entry version 178.
DE RecName: Full=Homeobox protein Hox-A10;
DE AltName: Full=Homeobox protein Hox-1.8;
GN Name=Hoxa10; Synonyms=Hox-1.8, Hoxa-10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=CD-1; TISSUE=Kidney;
RX PubMed=7862151; DOI=10.1128/mcb.15.3.1591;
RA Benson G.V., Nguyen T.-H.E., Maas R.L.;
RT "The expression pattern of the murine Hoxa-10 gene and the sequence
RT recognition of its homeodomain reveal specific properties of Abdominal B-
RT like genes.";
RL Mol. Cell. Biol. 15:1591-1601(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-416 (ISOFORM 1).
RC TISSUE=Limb;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 342-401.
RX PubMed=1683707; DOI=10.1073/pnas.88.23.10706;
RA Singh G., Kaur S., Stock J.L., Jenkins N.A., Gilbert D.J., Copeland N.G.,
RA Potter S.S.;
RT "Identification of 10 murine homeobox genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:10706-10710(1991).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 363-387.
RC STRAIN=C57BL/6J; TISSUE=Spleen;
RX PubMed=1720547; DOI=10.1073/pnas.88.23.10711;
RA Murtha M.T., Leckman J.F., Ruddle F.H.;
RT "Detection of homeobox genes in development and evolution.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:10711-10715(1991).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. Binds to the DNA
CC sequence 5'-AA[AT]TTTTATTAC-3'.
CC -!- SUBUNIT: Interacts with SIRT2; the interaction is direct.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=a10-1;
CC IsoId=P31310-1; Sequence=Displayed;
CC Name=2; Synonyms=a10-2;
CC IsoId=P31310-2; Sequence=VSP_002386, VSP_002387;
CC -!- TISSUE SPECIFICITY: Expressed in the developing limb bud where it is
CC restricted to the mesenchyme along the proximal-distal axis. Also found
CC in developing gut and urogenital tract. In adult tissue, both forms
CC found in kidney but only isoform 1 is expressed in skeletal muscle.
CC -!- DEVELOPMENTAL STAGE: Embryonic expression increases from day 9 to day
CC 12 and then declines to day 15.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA67125.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH50839.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L08757; AAA67125.1; ALT_INIT; mRNA.
DR EMBL; L08758; AAD15230.1; -; mRNA.
DR EMBL; BC050839; AAH50839.1; ALT_INIT; mRNA.
DR EMBL; M81659; AAA63312.1; -; Genomic_DNA.
DR CCDS; CCDS20147.2; -. [P31310-1]
DR CCDS; CCDS51775.1; -. [P31310-2]
DR PIR; I49754; I49754.
DR RefSeq; NP_001116422.1; NM_001122950.2. [P31310-2]
DR RefSeq; NP_032289.2; NM_008263.3. [P31310-1]
DR AlphaFoldDB; P31310; -.
DR SMR; P31310; -.
DR BioGRID; 200363; 20.
DR IntAct; P31310; 7.
DR STRING; 10090.ENSMUSP00000120276; -.
DR PhosphoSitePlus; P31310; -.
DR jPOST; P31310; -.
DR MaxQB; P31310; -.
DR PaxDb; P31310; -.
DR PRIDE; P31310; -.
DR ProteomicsDB; 267179; -. [P31310-1]
DR ProteomicsDB; 267180; -. [P31310-2]
DR Antibodypedia; 48441; 224 antibodies from 26 providers.
DR DNASU; 15395; -.
DR Ensembl; ENSMUST00000121043; ENSMUSP00000112872; ENSMUSG00000000938. [P31310-2]
DR Ensembl; ENSMUST00000125581; ENSMUSP00000120276; ENSMUSG00000000938. [P31310-1]
DR GeneID; 15395; -.
DR KEGG; mmu:15395; -.
DR UCSC; uc009bym.1; mouse. [P31310-1]
DR UCSC; uc012ema.1; mouse. [P31310-2]
DR CTD; 3206; -.
DR MGI; MGI:96171; Hoxa10.
DR VEuPathDB; HostDB:ENSMUSG00000000938; -.
DR eggNOG; KOG0487; Eukaryota.
DR GeneTree; ENSGT00940000162440; -.
DR HOGENOM; CLU_057871_0_0_1; -.
DR InParanoid; P31310; -.
DR OMA; YDSEKCP; -.
DR OrthoDB; 976319at2759; -.
DR PhylomeDB; P31310; -.
DR TreeFam; TF317819; -.
DR BioGRID-ORCS; 15395; 2 hits in 70 CRISPR screens.
DR ChiTaRS; Hoxa10; mouse.
DR PRO; PR:P31310; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P31310; protein.
DR Bgee; ENSMUSG00000000938; Expressed in gastrula and 151 other tissues.
DR Genevisible; P31310; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005667; C:transcription regulator complex; IDA:MGI.
DR GO; GO:0003677; F:DNA binding; TAS:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0042826; F:histone deacetylase binding; ISO:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
DR GO; GO:0030326; P:embryonic limb morphogenesis; IGI:MGI.
DR GO; GO:0008584; P:male gonad development; IGI:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0030850; P:prostate gland development; IEA:Ensembl.
DR GO; GO:0009954; P:proximal/distal pattern formation; IGI:MGI.
DR GO; GO:0010468; P:regulation of gene expression; IGI:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0043627; P:response to estrogen; IEA:Ensembl.
DR GO; GO:0033574; P:response to testosterone; IEA:Ensembl.
DR GO; GO:0007338; P:single fertilization; IGI:MGI.
DR GO; GO:0001501; P:skeletal system development; IGI:MGI.
DR GO; GO:0007283; P:spermatogenesis; IGI:MGI.
DR GO; GO:0060065; P:uterus development; IGI:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR046333; HXA10/ABDB-like.
DR PANTHER; PTHR45874; PTHR45874; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Developmental protein; DNA-binding; Homeobox;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..416
FT /note="Homeobox protein Hox-A10"
FT /id="PRO_0000200091"
FT DNA_BIND 342..401
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 40..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 81..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..160
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..322
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:7862151"
FT /id="VSP_002386"
FT VAR_SEQ 323..325
FT /note="DSL -> MSQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:7862151"
FT /id="VSP_002387"
FT CONFLICT 44
FT /note="V -> G (in Ref. 2; AAH50839)"
FT /evidence="ECO:0000305"
FT CONFLICT 241
FT /note="Q -> E (in Ref. 1; AAA67125)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 416 AA; 43292 MW; A088014205877F3E CRC64;
MSARKGYLLP SPNYPTTMSC SESPAANSFL VDSLISSGRG EAGVGGGSAG GGGGGYYAHG
GVYLPPASDL PYGLQSCGLF PALGSKRNEA PSPGGGGGGG SGGLGPGTHG YAPAPLDLWL
DAPRSCRMEP PDGPPPPQPQ PQQQQQQPPP PPPQPPQPQP QATSCSFAQN IKEESSYCLY
DAADKCPKGS AAADLAPFPR GPPPDGCALG ASSGVPVPGY FRLSQAYGTA KGFGSGGGGT
QQLASPFPAQ PPGRGFDPPP ALASGSTEAA GKERVLDSTP PPTLVCTGGG GSQGDEEAHA
SSSAAEELSP APSENSKASP EKDSLGSSKG ENAANWLTAK SGRKKRCPYT KHQTLELEKE
FLFNMYLTRE RRLEISRSVH LTDRQVKIWF QNRRMKLKKM NRENRIRELT ANFNFS
