HXA11_CHICK
ID HXA11_CHICK Reviewed; 297 AA.
AC P31258;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Homeobox protein Hox-A11;
DE AltName: Full=Ghox-1I;
DE AltName: Full=Homeobox protein Hox-1.9;
DE Short=Chox-1.9;
GN Name=HOXA11; Synonyms=GHOX1I;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1347239; DOI=10.1002/aja.1001930112;
RA Rogina B., Coelho C.N., Kosher R.A., Upholt W.B.;
RT "The pattern of expression of the chicken homolog of HOX1I in the
RT developing limb suggests a possible role in the ectodermal inhibition of
RT chondrogenesis.";
RL Dev. Dyn. 193:92-101(1992).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR EMBL; M81250; AAA48823.1; -; mRNA.
DR RefSeq; NP_989950.1; NM_204619.1.
DR AlphaFoldDB; P31258; -.
DR SMR; P31258; -.
DR STRING; 9031.ENSGALP00000042845; -.
DR PaxDb; P31258; -.
DR Ensembl; ENSGALT00000078475; ENSGALP00000046000; ENSGALG00000040021.
DR GeneID; 395327; -.
DR KEGG; gga:395327; -.
DR CTD; 3207; -.
DR VEuPathDB; HostDB:geneid_395327; -.
DR eggNOG; KOG0487; Eukaryota.
DR GeneTree; ENSGT00940000158311; -.
DR HOGENOM; CLU_079662_0_0_1; -.
DR InParanoid; P31258; -.
DR OMA; NVYHHPS; -.
DR OrthoDB; 976319at2759; -.
DR PhylomeDB; P31258; -.
DR PRO; PR:P31258; -.
DR Proteomes; UP000000539; Chromosome 2.
DR Bgee; ENSGALG00000040021; Expressed in colon and 3 other tissues.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0032993; C:protein-DNA complex; IEA:Ensembl.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
DR GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl.
DR GO; GO:0060351; P:cartilage development involved in endochondral bone morphogenesis; IEA:Ensembl.
DR GO; GO:0002063; P:chondrocyte development; IEA:Ensembl.
DR GO; GO:0048589; P:developmental growth; IEA:Ensembl.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:Ensembl.
DR GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
DR GO; GO:0035115; P:embryonic forelimb morphogenesis; IEA:Ensembl.
DR GO; GO:0060272; P:embryonic skeletal joint morphogenesis; IEA:Ensembl.
DR GO; GO:0008584; P:male gonad development; IEA:Ensembl.
DR GO; GO:0007501; P:mesodermal cell fate specification; IEA:Ensembl.
DR GO; GO:0001656; P:metanephros development; IEA:Ensembl.
DR GO; GO:0001759; P:organ induction; IEA:Ensembl.
DR GO; GO:1902761; P:positive regulation of chondrocyte development; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
DR GO; GO:0009954; P:proximal/distal pattern formation; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007338; P:single fertilization; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR GO; GO:0060065; P:uterus development; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR021918; DUF3528.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF12045; DUF3528; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..297
FT /note="Homeobox protein Hox-A11"
FT /id="PRO_0000200097"
FT DNA_BIND 225..284
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 151..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 297 AA; 33273 MW; 943B19F9CF3F7C74 CRC64;
MMDFDERVPC SSNMYLPSCT YYVSGPDFSS LPSFLPQTPS SRPMTYSYSS NLPQVQPVRE
VTFREYAIDP SSKWHPRNNL PHCYSAEEIM HRDCLPSTTT ASMGEVFGKS TANVYHHPSA
NVSSNFYSTV GRNGVLPQAF DQFFETAYGT AENPSSADYP PDKSGEKAPA AAGATAATSS
SEGGCGGAAA AAGKERRRRP ESGSSPESSS GNNEEKSGSS SGQRTRKKRC PYTKYQIREL
EREFFFSVYI NKEKRLQLSR MLNLTDRQVK IWFQNRRMKE KKINRDRLQY YSANPLL
