HXA11_MOUSE
ID HXA11_MOUSE Reviewed; 313 AA.
AC P31311; Q3V026;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 2.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=Homeobox protein Hox-A11;
DE AltName: Full=Homeobox protein Hox-1.9;
GN Name=Hoxa11; Synonyms=Hox-1.9, Hoxa-11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=7789268; DOI=10.1242/dev.121.5.1373;
RA Hsieh-Li H.M., Witte D.P., Weinstein M., Branford W., Li H., Small K.,
RA Potter S.S.;
RT "Hoxa 11 structure, extensive antisense transcription, and function in male
RT and female fertility.";
RL Development 121:1373-1385(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 241-300.
RX PubMed=1683707; DOI=10.1073/pnas.88.23.10706;
RA Singh G., Kaur S., Stock J.L., Jenkins N.A., Gilbert D.J., Copeland N.G.,
RA Potter S.S.;
RT "Identification of 10 murine homeobox genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:10706-10710(1991).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- INTERACTION:
CC P31311; O88513: Gmnn; NbExp=2; IntAct=EBI-445941, EBI-445922;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR EMBL; U20371; AAA85711.1; -; Genomic_DNA.
DR EMBL; U20370; AAA85710.1; -; mRNA.
DR EMBL; AK133481; BAE21679.1; -; mRNA.
DR EMBL; BC119302; AAI19303.1; -; mRNA.
DR CCDS; CCDS20148.1; -.
DR PIR; G37290; G37290.
DR RefSeq; NP_034580.1; NM_010450.3.
DR AlphaFoldDB; P31311; -.
DR SMR; P31311; -.
DR BioGRID; 200364; 8.
DR IntAct; P31311; 7.
DR STRING; 10090.ENSMUSP00000040920; -.
DR iPTMnet; P31311; -.
DR PhosphoSitePlus; P31311; -.
DR PaxDb; P31311; -.
DR PRIDE; P31311; -.
DR ProteomicsDB; 273228; -.
DR Antibodypedia; 12408; 370 antibodies from 33 providers.
DR DNASU; 15396; -.
DR Ensembl; ENSMUST00000048026; ENSMUSP00000040920; ENSMUSG00000038210.
DR GeneID; 15396; -.
DR KEGG; mmu:15396; -.
DR UCSC; uc009byn.2; mouse.
DR CTD; 3207; -.
DR MGI; MGI:96172; Hoxa11.
DR VEuPathDB; HostDB:ENSMUSG00000038210; -.
DR eggNOG; KOG0487; Eukaryota.
DR GeneTree; ENSGT00940000158311; -.
DR HOGENOM; CLU_079662_0_0_1; -.
DR InParanoid; P31311; -.
DR OMA; NVYHHPS; -.
DR OrthoDB; 976319at2759; -.
DR PhylomeDB; P31311; -.
DR TreeFam; TF350668; -.
DR BioGRID-ORCS; 15396; 2 hits in 75 CRISPR screens.
DR ChiTaRS; Hoxa11; mouse.
DR PRO; PR:P31311; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P31311; protein.
DR Bgee; ENSMUSG00000038210; Expressed in gastrula and 81 other tissues.
DR Genevisible; P31311; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB.
DR GO; GO:0032993; C:protein-DNA complex; IDA:UniProtKB.
DR GO; GO:0005667; C:transcription regulator complex; IDA:MGI.
DR GO; GO:0003677; F:DNA binding; TAS:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
DR GO; GO:0060348; P:bone development; IMP:MGI.
DR GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IGI:MGI.
DR GO; GO:0060351; P:cartilage development involved in endochondral bone morphogenesis; IGI:MGI.
DR GO; GO:0048468; P:cell development; IGI:MGI.
DR GO; GO:0002063; P:chondrocyte development; IGI:MGI.
DR GO; GO:0002062; P:chondrocyte differentiation; IGI:MGI.
DR GO; GO:0048589; P:developmental growth; IGI:MGI.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IGI:MGI.
DR GO; GO:0042733; P:embryonic digit morphogenesis; IGI:MGI.
DR GO; GO:0035115; P:embryonic forelimb morphogenesis; IGI:MGI.
DR GO; GO:0030326; P:embryonic limb morphogenesis; IGI:MGI.
DR GO; GO:0060272; P:embryonic skeletal joint morphogenesis; IGI:MGI.
DR GO; GO:0008584; P:male gonad development; IMP:MGI.
DR GO; GO:0007501; P:mesodermal cell fate specification; IDA:UniProtKB.
DR GO; GO:0001656; P:metanephros development; IGI:MGI.
DR GO; GO:0001759; P:organ induction; IGI:MGI.
DR GO; GO:1902761; P:positive regulation of chondrocyte development; IGI:MGI.
DR GO; GO:0032332; P:positive regulation of chondrocyte differentiation; IGI:MGI.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0030850; P:prostate gland development; IEA:Ensembl.
DR GO; GO:0009954; P:proximal/distal pattern formation; IGI:MGI.
DR GO; GO:0032330; P:regulation of chondrocyte differentiation; IGI:MGI.
DR GO; GO:0010468; P:regulation of gene expression; IGI:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0043627; P:response to estrogen; IEA:Ensembl.
DR GO; GO:0033574; P:response to testosterone; IEA:Ensembl.
DR GO; GO:0007338; P:single fertilization; IMP:MGI.
DR GO; GO:0001501; P:skeletal system development; IMP:MGI.
DR GO; GO:0007283; P:spermatogenesis; IMP:MGI.
DR GO; GO:0060065; P:uterus development; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR021918; DUF3528.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF12045; DUF3528; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..313
FT /note="Homeobox protein Hox-A11"
FT /id="PRO_0000200096"
FT DNA_BIND 241..300
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 188..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..219
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 313 AA; 34484 MW; 07BE80F8E2225B3E CRC64;
MMDFDERGPC SSNMYLPSCT YYVSGPDFSS LPSFLPQTPS SRPMTYSYSS NLPQVQPVRE
VTFREYAIEP ATKWHPRGNL AHCYSAEELV HRDCLQAPSA AGVPGDVLAK SSANVYHHPT
PAVSSNFYST VGRNGVLPQA FDQFFETAYG TPENLASSDY PGDKNAEKGP QAAAATSAAA
VAAAATGAPA TSSSDGGGGG GCQEAAAEEK ERRRRPESSS SPESSSGHTE DKAGGSGGQR
TRKKRCPYTK YQIRELEREF FFSVYINKEK RLQLSRMLNL TDRQVKIWFQ NRRMKEKKIN
RDRLQYYSAN PLL
