HXA13_AMBME
ID HXA13_AMBME Reviewed; 107 AA.
AC P50210;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Homeobox protein Hox-A13;
DE Flags: Fragment;
GN Name=HOXA13;
OS Ambystoma mexicanum (Axolotl).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Caudata; Salamandroidea; Ambystomatidae; Ambystoma.
OX NCBI_TaxID=8296;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Regenerating limb blastema;
RX PubMed=7600989; DOI=10.1242/dev.121.6.1731;
RA Gardiner D.M., Blumberg B., Komine Y., Bryant S.V.;
RT "Regulation of HoxA expression in developing and regenerating axolotl
RT limbs.";
RL Development 121:1731-1741(1995).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR EMBL; U20942; AAA86506.1; -; mRNA.
DR AlphaFoldDB; P50210; -.
DR BMRB; P50210; -.
DR SMR; P50210; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW Transcription regulation.
FT CHAIN <1..107
FT /note="Homeobox protein Hox-A13"
FT /id="PRO_0000200106"
FT DNA_BIND 41..100
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT NON_TER 1
SQ SEQUENCE 107 AA; 12746 MW; 005AA4982C8C79E3 CRC64;
TNGWNGQVYC SKEQGQPPHL WKSSLPDVVW HPSDANSYRR GRKKRVPYTK VQLKELEREY
ATNKFITKDK RRRISATTNL SERQVTIWFQ NRRVKEKKVI NKLKTTS