ID   HXA13_CHICK             Reviewed;         290 AA.
AC   Q90X25;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Homeobox protein Hox-A13;
GN   Name=HOXA13;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   de Santa Barbara P., Roberts D.J.;
RT   "Hoxa-13 function in the posterior gut endoderm.";
RL   Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sequence-specific, AT-rich binding transcription factor which
CC       is part of a developmental regulatory system that provides cells with
CC       specific positional identities on the anterior-posterior axis.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Binds DNA as a homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR   EMBL; AY030050; AAK38163.1; -; mRNA.
DR   RefSeq; NP_989470.1; NM_204139.1.
DR   AlphaFoldDB; Q90X25; -.
DR   BMRB; Q90X25; -.
DR   SMR; Q90X25; -.
DR   STRING; 9031.ENSGALP00000043198; -.
DR   PaxDb; Q90X25; -.
DR   GeneID; 373934; -.
DR   KEGG; gga:373934; -.
DR   CTD; 3209; -.
DR   VEuPathDB; HostDB:geneid_373934; -.
DR   eggNOG; KOG0487; Eukaryota.
DR   HOGENOM; CLU_059940_1_0_1; -.
DR   InParanoid; Q90X25; -.
DR   OrthoDB; 1190384at2759; -.
DR   PhylomeDB; Q90X25; -.
DR   PRO; PR:Q90X25; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR022067; HoxA13_N.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF12284; HoxA13_N; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..290
FT                   /note="Homeobox protein Hox-A13"
FT                   /id="PRO_0000200103"
FT   DNA_BIND        224..283
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ   SEQUENCE   290 AA;  31944 MW;  F742BA75DF3E6E13 CRC64;
     MFLYDNSLDE INKNMDGFHA GSNFAAAAAA NPCRNLMAHP APLAAPSAAA YTSSEAPAAG
     MAEPAVKQCS PCSAAVQSSS GAALPYGYFG SGYYPCRMTH HNAIKSCAQP ASTFADKYMD
     TSVSGEEFTS RAKEFAFYQG YAAGPYQPVP GYLDVPVVPT IGGPGEPRHD SLLPMDSYQP
     WAITNGWNGQ VYCPKEQSQP PHLWKSTLPD VVSHPSDANS YRRGRKKRVP YTKVQLKELE
     REYATNKFIT KDKRRRISAT TNLSERQVTI WFQNRRVKEK KVINKLKTTS