ID   HXA1A_TAKRU             Reviewed;         325 AA.
AC   Q1KL10;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Homeobox protein Hox-A1a;
GN   Name=hoxa1a;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16636282; DOI=10.1073/pnas.0601492103;
RA   Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.;
RT   "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved
RT   regulatory elements within and outside Hox gene clusters.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. Labial subfamily.
CC       {ECO:0000305}.
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DR   EMBL; DQ481663; ABF22384.1; -; Genomic_DNA.
DR   RefSeq; XP_011607394.1; XM_011609092.1.
DR   AlphaFoldDB; Q1KL10; -.
DR   SMR; Q1KL10; -.
DR   STRING; 31033.ENSTRUP00000040749; -.
DR   GeneID; 101067786; -.
DR   KEGG; tru:101067786; -.
DR   CTD; 58051; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   InParanoid; Q1KL10; -.
DR   OrthoDB; 1216870at2759; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR046327; HXA1/B1/D1.
DR   PANTHER; PTHR45946; PTHR45946; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..325
FT                   /note="Homeobox protein Hox-A1a"
FT                   /id="PRO_0000265962"
FT   DNA_BIND        212..271
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          194..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          264..325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           187..192
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        285..299
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        300..325
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   325 AA;  35189 MW;  279AFA93A0A94DCD CRC64;
     MSSFLDYSVM SGEGSSCSVR AFHSDHGITT FQSCAVSVNN CGTDDRFMAS RASPDGIPHQ
     SYQAAVSSLG LAYGAHSACS SSYAPQSFCT TYNHYPLNQE VEPAAGFPQC GPLMYSGNIS
     SSVVSQHRQG YGTTPLGQLQ YTHSAYGAGH EQPSPFTGCS NPLSPLHAAH LEACCSPLSE
     SASSAQTFDW MKVKRNPPKT GRSGEYGYGG QPNTVRTNFT TKQLTELEKE FHFNKYLTRA
     RRVEIAAALQ LNETQVKIWF QNRRMKQKKR EKEGLLPTKP TSSDSGERNQ EKVEDGESEK
     SVSAPSTPSP TSSTVSSGAD SYPSN