ID   HXA1_HETFR              Reviewed;         326 AA.
AC   Q9IA19;
DT   11-JUL-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Homeobox protein Hox-A1;
GN   Name=HOXA1;
OS   Heterodontus francisci (Horn shark) (Cestracion francisci).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Heterodontoidea; Heterodontiformes;
OC   Heterodontidae; Heterodontus.
OX   NCBI_TaxID=7792;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10677514; DOI=10.1073/pnas.030539697;
RA   Kim C.B., Amemiya C., Bailey W., Kawasaki K., Mezey J., Miller W.,
RA   Minoshima S., Shimizu N., Wagner G., Ruddle F.;
RT   "Hox cluster genomics in the horn shark, Heterodontus francisci.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:1655-1660(2000).
CC   -!- FUNCTION: Sequence-specific transcription factor. Part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. Acts on the
CC       anterior body structures. Seems to act in the maintenance and/or
CC       generation of hindbrain segments. {ECO:0000250|UniProtKB:Q90423}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. Labial subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF224262; AAF44639.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9IA19; -.
DR   SMR; Q9IA19; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR046327; HXA1/B1/D1.
DR   PANTHER; PTHR45946; PTHR45946; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..326
FT                   /note="Homeobox protein Hox-A1"
FT                   /id="PRO_0000200034"
FT   DNA_BIND        221..280
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          273..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           196..201
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        287..326
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   326 AA;  35419 MW;  02485F6224C65028 CRC64;
     MDNARMNSFL DYSIINGETG TCSSRSYHAD QGITTYQSCA VSNNNCNADD RYIVSRSVQI
     GAPPPHHHHH QSNYTHPNNL GISYSAHPNC GAGYPAQSFN TGYSHHYSLN QETDGNGGYP
     QCAPAVYPGN IASAISPHHH SYGGMVGSGQ YPHHPYGQEQ QGLALAAGCH SLSPVHGSHQ
     EACCSPSAET PPPAQTFDWM KVKRNPPKTG KAGEYGFAGQ PNTVRTNFTT KQLTELEKEF
     HFNKYLTRAR RVEIAAALQL NETQVKIWFQ NRRMKQKKRE KEGLTSASPA TPGSEANTED
     TSDKCNSTSS TPSPSSSTSE TINTSG