HXA1_RAT
ID HXA1_RAT Reviewed; 333 AA.
AC O08656;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 25-MAY-2022, entry version 135.
DE RecName: Full=Homeobox protein Hox-A1;
GN Name=Hoxa1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pancreas;
RA Cook T., Urrutia R.;
RL Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sequence-specific transcription factor (By similarity).
CC Regulates multiple developmental processes including brainstem, inner
CC and outer ear, abducens nerve and cardiovascular development and
CC morphogenesis as well as cognition and behavior (By similarity). Also
CC part of a developmental regulatory system that provides cells with
CC specific positional identities on the anterior-posterior axis. Acts on
CC the anterior body structures. Seems to act in the maintenance and/or
CC generation of hindbrain segments (By similarity). Activates
CC transcription in the presence of PBX1A and PKNOX1 (By similarity).
CC {ECO:0000250|UniProtKB:P09022, ECO:0000250|UniProtKB:P49639,
CC ECO:0000250|UniProtKB:Q90423}.
CC -!- SUBUNIT: Interacts with OGT (via TPR repeats domain); the interaction
CC takes place mainly in the nucleus (By similarity). Forms a DNA-binding
CC heterodimer with transcription factor PBX1 (By similarity).
CC {ECO:0000250|UniProtKB:P49639}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- PTM: Glycosylated by OGT. {ECO:0000250|UniProtKB:P09022}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. Labial subfamily.
CC {ECO:0000305}.
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DR EMBL; U93092; AAB51399.1; -; mRNA.
DR AlphaFoldDB; O08656; -.
DR SMR; O08656; -.
DR STRING; 10116.ENSRNOP00000007807; -.
DR GlyGen; O08656; 1 site.
DR PaxDb; O08656; -.
DR UCSC; RGD:2812; rat.
DR RGD; 11414885; Hoxa1.
DR eggNOG; KOG0489; Eukaryota.
DR InParanoid; O08656; -.
DR PhylomeDB; O08656; -.
DR PRO; PR:O08656; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:RGD.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0021599; P:abducens nerve formation; ISO:RGD.
DR GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; ISO:RGD.
DR GO; GO:0009653; P:anatomical structure morphogenesis; ISO:RGD.
DR GO; GO:0009952; P:anterior/posterior pattern specification; ISO:RGD.
DR GO; GO:0060840; P:artery development; ISO:RGD.
DR GO; GO:0048844; P:artery morphogenesis; ISO:RGD.
DR GO; GO:0071361; P:cellular response to ethanol; ISO:RGD.
DR GO; GO:0071300; P:cellular response to retinoic acid; ISO:RGD.
DR GO; GO:0021953; P:central nervous system neuron differentiation; ISO:RGD.
DR GO; GO:0090102; P:cochlea development; ISO:RGD.
DR GO; GO:0090103; P:cochlea morphogenesis; ISO:RGD.
DR GO; GO:0050890; P:cognition; ISO:RGD.
DR GO; GO:0048702; P:embryonic neurocranium morphogenesis; ISO:RGD.
DR GO; GO:0021612; P:facial nerve structural organization; ISO:RGD.
DR GO; GO:0021754; P:facial nucleus development; ISO:RGD.
DR GO; GO:0030902; P:hindbrain development; ISO:RGD.
DR GO; GO:0048839; P:inner ear development; ISO:RGD.
DR GO; GO:0042472; P:inner ear morphogenesis; ISO:RGD.
DR GO; GO:0008045; P:motor neuron axon guidance; ISO:RGD.
DR GO; GO:0007399; P:nervous system development; ISO:RGD.
DR GO; GO:0050905; P:neuromuscular process; ISO:RGD.
DR GO; GO:0007634; P:optokinetic behavior; ISO:RGD.
DR GO; GO:0042473; P:outer ear morphogenesis; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0050795; P:regulation of behavior; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0021569; P:rhombomere 3 development; ISO:RGD.
DR GO; GO:0021570; P:rhombomere 4 development; ISO:RGD.
DR GO; GO:0021571; P:rhombomere 5 development; ISO:RGD.
DR GO; GO:0060876; P:semicircular canal formation; ISO:RGD.
DR GO; GO:0007605; P:sensory perception of sound; ISO:RGD.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR046327; HXA1/B1/D1.
DR PANTHER; PTHR45946; PTHR45946; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Glycoprotein; Homeobox; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..333
FT /note="Homeobox protein Hox-A1"
FT /id="PRO_0000200032"
FT DNA_BIND 227..286
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 61..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 74..202
FT /note="Interaction with OGT"
FT /evidence="ECO:0000250|UniProtKB:P09022"
FT REGION 279..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 203..208
FT /note="Antp-type hexapeptide"
FT COMPBIAS 311..333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 152
FT /note="O-linked (GlcNAc) threonine"
FT /evidence="ECO:0000250|UniProtKB:P09022"
SQ SEQUENCE 333 AA; 36124 MW; 54BB793C378E22E1 CRC64;
MDNARLNSFL EYPILGSGDS GTCSARVYSS DHGITTFQSC AVSANSCGGD DRFLGGRGVQ
ITSPHHHHHH HHHPQPATYQ TSGNLGVSYS HSSCGPSYGA QNFSAPYGPY GLNQEADVSG
GYPPCAPAVY SGNLSSPMVQ HHHHHQGYAG GTVGSPQYIH HSYGQEHQSL ALATYNNSLS
PLHASHQEAC RSPASETSSP AQTFDWMKVK RNPPKTGKVG EYGYVGQPNA VRTNFTTKQL
TELEKEFHFN KYLTRARSEI AASLQLNETQ VKIWFQNRRM KQKKREKEGL LPMSPATPPG
SDEKTEESSE KSSSSPSAPS PASSTSDTLT TSH
