ID   HXA1_XENLA              Reviewed;         240 AA.
AC   Q08821;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Homeobox protein Hox-A1;
DE   AltName: Full=Hox.lab2;
DE   Flags: Fragment;
GN   Name=hoxa1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1678362; DOI=10.1101/gad.5.8.1321;
RA   Sive H.L., Cheng P.F.;
RT   "Retinoic acid perturbs the expression of Xhox.lab genes and alters
RT   mesodermal determination in Xenopus laevis.";
RL   Genes Dev. 5:1321-1332(1991).
CC   -!- FUNCTION: Sequence-specific transcription factor. Part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. Acts on the
CC       anterior body structures. Seems to act in the maintenance and/or
CC       generation of hindbrain segments. {ECO:0000250|UniProtKB:Q90423}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P09022}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. Labial subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X62053; CAA43981.1; -; mRNA.
DR   EMBL; L25856; AAA03479.1; -; mRNA.
DR   PIR; B40357; B40357.
DR   AlphaFoldDB; Q08821; -.
DR   SMR; Q08821; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR046327; HXA1/B1/D1.
DR   PANTHER; PTHR45946; PTHR45946; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           <1..240
FT                   /note="Homeobox protein Hox-A1"
FT                   /id="PRO_0000200035"
FT   DNA_BIND        134..193
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          186..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           109..114
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        218..240
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   240 AA;  26585 MW;  1CE50299E305D2FE CRC64;
     AYAHSSCGSN YGMQNFSPGY SHFPIHQETE VSSGFPQSVY SGNIASSVVQ HQQHQSYIEG
     SAHYIHHSYG PEQNLSVANY NNNVASLHIS QREVCHSPSS ETSPGPTQTF DWMKVKRNPP
     KTGKAGEYGY AGQPNTARTN FTTKQLTELE KEFHFNKYLT RARRVEIAAA LQLNETQVKI
     WFQNRRMKQK KREKEGLLPI SPSTSTGSDE KSEELSEKSN SSPCAPSPAS STSDHLSASG