ID   HXA2A_TAKRU             Reviewed;         363 AA.
AC   Q1KL11;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Homeobox protein Hox-A2a;
GN   Name=hoxa2a;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16636282; DOI=10.1073/pnas.0601492103;
RA   Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.;
RT   "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved
RT   regulatory elements within and outside Hox gene clusters.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. Proboscipedia
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DQ481663; ABF22383.1; -; Genomic_DNA.
DR   RefSeq; XP_003969027.1; XM_003968978.2.
DR   AlphaFoldDB; Q1KL11; -.
DR   SMR; Q1KL11; -.
DR   Ensembl; ENSTRUT00000040902; ENSTRUP00000040760; ENSTRUG00000015941.
DR   GeneID; 101068014; -.
DR   KEGG; tru:101068014; -.
DR   GeneTree; ENSGT00940000155029; -.
DR   InParanoid; Q1KL11; -.
DR   OrthoDB; 835724at2759; -.
DR   Proteomes; UP000005226; Chromosome 12.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..363
FT                   /note="Homeobox protein Hox-A2a"
FT                   /id="PRO_0000265963"
FT   DNA_BIND        137..196
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          30..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          98..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          189..220
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          268..308
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           88..93
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        30..48
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        102..117
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        197..214
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        268..301
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   363 AA;  39783 MW;  51673DF29AC0EC56 CRC64;
     MNYEFERESG FINSQPSLAE CLTSFPPVAD SFQSSSIKSS TLSRPTLIPP PFEQTIPSLN
     PGSHPRHGRP RHSPDGCSPL PTASLPPEYP WMREKKASKR NHLPNSTTTT ISNGPVCFSP
     KGSPEIVESA GGGGGGSRRL RTAYTNTQLL ELEKEFHFNK YLCRPRRVEI AALLDLTERQ
     VKVWFQNRRM KHKRQTQSKE NHNAEGKGPS TEEGIHSDEE DEAPVFDRSG ALLERDTCSF
     QKKSHGSAQQ HHNSVSMGFA AAPLNSNDKN LKHFPNPSPT VPGCMSTIGP GSASGPDNSD
     SPPALDVSIH DFQPFSSDSC LQLSDAASPS LSESLDSPVD ISTDSFYFFS ESLTTIDLQH
     LSY