HXA2B_DANRE
ID HXA2B_DANRE Reviewed; 363 AA.
AC O42365; Q4PRA7; Q9DEZ0;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Homeobox protein Hox-A2b;
DE Short=Hox-A2;
GN Name=hoxa2b; Synonyms=hoxa2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11076758; DOI=10.1242/dev.127.24.5367;
RA Pasqualetti M., Ori M., Nardi I., Rijli F.M.;
RT "Ectopic Hoxa2 induction after neural crest migration results in homeosis
RT of jaw elements in Xenopus.";
RL Development 127:5367-5378(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 45-132.
RC STRAIN=Tuebingen;
RX PubMed=16174031; DOI=10.1111/j.1525-142x.2005.05042.x;
RA Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T.,
RA de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J.,
RA Richardson M.K.;
RT "Genomic annotation and transcriptome analysis of the zebrafish (Danio
RT rerio) hox complex with description of a novel member, hoxb13a.";
RL Evol. Dev. 7:362-375(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 165-363, AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo;
RX PubMed=9425135; DOI=10.1242/dev.125.3.393;
RA Prince V.E., Moens C.B., Kimmel C.B., Ho R.K.;
RT "Zebrafish hox genes: expression in the hindbrain region of wild-type and
RT mutants of the segmentation gene, valentino.";
RL Development 125:393-406(1998).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: First expressed at the 2-somite stage as a stripe
CC in the region of the hindbrain that will give rise to rhombomeres 2 and
CC 3. By the 10-somite stage, expression has expanded posteriorly to
CC rhombomeres 4 and 5. {ECO:0000269|PubMed:9425135}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. Proboscipedia
CC subfamily. {ECO:0000305}.
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DR EMBL; AF307010; AAG30510.1; -; mRNA.
DR EMBL; AL645795; CAD59108.1; -; Genomic_DNA.
DR EMBL; DQ060536; AAY67914.1; -; mRNA.
DR EMBL; Y13945; CAA74283.1; -; mRNA.
DR RefSeq; NP_571181.1; NM_131106.1.
DR AlphaFoldDB; O42365; -.
DR SMR; O42365; -.
DR BioGRID; 78532; 1.
DR STRING; 7955.ENSDARP00000023072; -.
DR PaxDb; O42365; -.
DR GeneID; 30325; -.
DR KEGG; dre:30325; -.
DR CTD; 30325; -.
DR ZFIN; ZDB-GENE-990415-98; hoxa2b.
DR eggNOG; KOG0489; Eukaryota.
DR InParanoid; O42365; -.
DR OrthoDB; 835724at2759; -.
DR PhylomeDB; O42365; -.
DR PRO; PR:O42365; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..363
FT /note="Homeobox protein Hox-A2b"
FT /id="PRO_0000200040"
FT DNA_BIND 133..192
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 42..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 88..93
FT /note="Antp-type hexapeptide"
FT COMPBIAS 42..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 360
FT /note="H -> P (in Ref. 4; CAA74283)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 363 AA; 39814 MW; 2808F51BBD3A8B6E CRC64;
MNYEFERETG FINSQPSLAE CLTSFPPVGD AFQSSSIKSS TLSHSTLIPP PFEQTIPSLN
PGSHPRHSRP KQNPNGSCPL PAASLPPEYP WMKEKKASKK NQTTSTAATT DPGPLYFSPQ
GSPEISDGGS GATRRLRTAY TNTQLLELEK EFHFNKYLCR PRRVEIAALL DLTERQVKVW
FQNRRMKHKR QTQCKENHHG DGKPPSLEEA GGRGDGKSFF EQVANNVSGA LLEREGYPFQ
QNTLTSQQSQ NGHNSDSQSA TVSPLGSNDK HLKHFPNPSP TVPICTTTMA PDCASAQDNG
SPSALDVSLQ DFNVFSNDSC LHLSDAVSPS LSESVDSPIG LTTEAFDFFS ETLTTIDLQH
LSY
