HXA2_CHICK
ID HXA2_CHICK Reviewed; 375 AA.
AC Q08727;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Homeobox protein Hox-A2;
GN Name=HOXA2; Synonyms=HOXA-2;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7600967; DOI=10.1242/dev.120.4.911;
RA Prince V.E., Lumsden A.;
RT "Hoxa-2 expression in normal and transposed rhombomeres: independent
RT regulation in the neural tube and neural crest.";
RL Development 120:911-923(1994).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. Proboscipedia
CC subfamily. {ECO:0000305}.
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DR EMBL; X74323; CAA52370.1; -; mRNA.
DR PIR; I50589; I50589.
DR PIR; S35941; S35941.
DR RefSeq; NP_990481.1; NM_205150.2.
DR AlphaFoldDB; Q08727; -.
DR SMR; Q08727; -.
DR BioGRID; 676323; 1.
DR STRING; 9031.ENSGALP00000017982; -.
DR Ensembl; ENSGALT00000052233; ENSGALP00000044883; ENSGALG00000040521.
DR GeneID; 396055; -.
DR KEGG; gga:396055; -.
DR CTD; 3199; -.
DR VEuPathDB; HostDB:geneid_396055; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000155029; -.
DR HOGENOM; CLU_048378_0_0_1; -.
DR InParanoid; Q08727; -.
DR OMA; ACLGHKE; -.
DR OrthoDB; 835724at2759; -.
DR PhylomeDB; Q08727; -.
DR PRO; PR:Q08727; -.
DR Proteomes; UP000000539; Chromosome 2.
DR Bgee; ENSGALG00000040521; Expressed in ovary and 7 other tissues.
DR ExpressionAtlas; Q08727; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..375
FT /note="Homeobox protein Hox-A2"
FT /id="PRO_0000200039"
FT DNA_BIND 140..199
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 29..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 255..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 94..99
FT /note="Antp-type hexapeptide"
FT COMPBIAS 29..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 375 AA; 40998 MW; C7C4CA10455C3B11 CRC64;
MNFEFEREIG FINSQPSLAE CLTSFPPVGD TFQSSSIKNS TLSHSTLIPP PFEQTIPSLN
PGGHPRHSGG GRPKASPRAR SGSPGPAGAP PPPEYPWMKE KKASKRSSLP PASASASAAG
PACLSHKDPL EIPDSGSGGS RRLRTAYTNT QLLELEKEFH FNKYLCRPRR VEIAALLDLT
ERQVKVWFQN RRMKHKRQTQ CKENQNGEGK FKGSEDPEKA AEDDEEEKAL FEQALGTVSG
ALLEREGYAF QQNALSQQQA QNAHNGESQS FPVSPLTSNE KNLKHFQHQS PTVQNCLSTM
AQNCAAGLNN DSPEALEVPS LQDFNVFSTD SCLQLSDAVS PSLPGSLDSP VDISADSFDF
FTDTLTTIDL QHLNY