ID   HXA2_HETFR              Reviewed;         363 AA.
AC   Q9IA20;
DT   11-JUL-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Homeobox protein Hox-A2;
GN   Name=HOXA2;
OS   Heterodontus francisci (Horn shark) (Cestracion francisci).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Heterodontoidea; Heterodontiformes;
OC   Heterodontidae; Heterodontus.
OX   NCBI_TaxID=7792;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10677514; DOI=10.1073/pnas.030539697;
RA   Kim C.B., Amemiya C., Bailey W., Kawasaki K., Mezey J., Miller W.,
RA   Minoshima S., Shimizu N., Wagner G., Ruddle F.;
RT   "Hox cluster genomics in the horn shark, Heterodontus francisci.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:1655-1660(2000).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. Proboscipedia
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AF224262; AAF44640.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9IA20; -.
DR   SMR; Q9IA20; -.
DR   PRIDE; Q9IA20; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..363
FT                   /note="Homeobox protein Hox-A2"
FT                   /id="PRO_0000200041"
FT   DNA_BIND        130..189
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          23..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          183..216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           88..93
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        23..79
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        102..123
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        189..216
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   363 AA;  40473 MW;  BE26080D9D255105 CRC64;
     MNYEFEREIG FINSQPSLAE CLTSFPPVGD TFQSSSIKNS TLSHSTVIPP PFEQTIPSLN
     PSSHPRQSRP KQSPNGTSPL PAATLPPEYP WMKEKKNSKK NHLPASSGPA ASCLSQKETH
     EIPDNTGGGS RRLRTAYTNT QLLELEKEFH FNKYLCRPRR VEIAALLDLT ERQVKVWFQN
     RRMKHKRQTQ CKENQNGDGK FKNLEDSGQT EDDEEKSLFE QGINNVTGAL LDREGYTFQS
     NALTQQQAQN LHNGESQSFP VSPLPSNEKN LKHFHQQSPT VQNCLSTMAQ NCAAGLNNDS
     PEALDVPSLQ DFNVFSTESC LQLSDGVSPS LPGSLDSPVD LSADSFDFFT DTLTTIDLQH
     LNY