ID   HXA2_NOTVI              Reviewed;          90 AA.
AC   P31261;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Homeobox protein Hox-A2;
DE   AltName: Full=Homeobox protein Hbox-2.8;
DE            Short=NvHbox-2.8;
DE   Flags: Fragment;
OS   Notophthalmus viridescens (Eastern newt) (Triturus viridescens).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Caudata; Salamandroidea; Salamandridae; Pleurodelinae;
OC   Notophthalmus.
OX   NCBI_TaxID=8316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1351019; DOI=10.1016/0378-1119(92)90572-7;
RA   Belleville S., Beauchemin M., Tremblay M., Noiseux N., Savard P.;
RT   "Homeobox-containing genes in the newt are organized in clusters similar to
RT   other vertebrates.";
RL   Gene 114:179-186(1992).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; M84002; AAA49396.1; -; Genomic_DNA.
DR   PIR; JC1163; JC1163.
DR   AlphaFoldDB; P31261; -.
DR   SMR; P31261; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           <1..>90
FT                   /note="Homeobox protein Hox-A2"
FT                   /id="PRO_0000200042"
FT   DNA_BIND        2..61
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          55..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..90
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         90
SQ   SEQUENCE   90 AA;  10764 MW;  C9F486132E2B1FA7 CRC64;
     GSRRLRTAYT NTQLLELEKE FHFNKYLCRP RRVEIAALLD LTERQVKVWF QNRRMKHKRQ
     TQCKENQNGE GKGKGLEEGD RSEDEEEKAL