ID   HXA3A_DANRE             Reviewed;         410 AA.
AC   Q8AWZ2; Q1L969; Q4PRB1; Q9YGT7;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Homeobox protein Hox-A3a;
GN   Name=hoxa3a; Synonyms=hoxa1a;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9831563; DOI=10.1126/science.282.5394.1711;
RA   Amores A., Force A., Yan Y.-L., Joly L., Amemiya C., Fritz A., Ho R.K.,
RA   Langeland J., Prince V.E., Wang Y.-L., Westerfield M., Ekker M.,
RA   Postlethwait J.H.;
RT   "Zebrafish hox clusters and vertebrate genome evolution.";
RL   Science 282:1711-1714(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 65-154.
RC   STRAIN=Tuebingen;
RX   PubMed=16174031; DOI=10.1111/j.1525-142x.2005.05042.x;
RA   Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T.,
RA   de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J.,
RA   Richardson M.K.;
RT   "Genomic annotation and transcriptome analysis of the zebrafish (Danio
RT   rerio) hox complex with description of a novel member, hoxb13a.";
RL   Evol. Dev. 7:362-375(2005).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; AF071245; AAD15938.1; -; mRNA.
DR   EMBL; AL645756; CAD52134.1; -; Genomic_DNA.
DR   EMBL; CR382300; CAK10851.1; -; Genomic_DNA.
DR   EMBL; BC076469; AAH76469.1; -; mRNA.
DR   EMBL; DQ060532; AAY67910.1; -; mRNA.
DR   RefSeq; NP_571609.1; NM_131534.1.
DR   AlphaFoldDB; Q8AWZ2; -.
DR   SMR; Q8AWZ2; -.
DR   STRING; 7955.ENSDARP00000117324; -.
DR   PaxDb; Q8AWZ2; -.
DR   Ensembl; ENSDART00000163611; ENSDARP00000130226; ENSDARG00000103862.
DR   Ensembl; ENSDART00000170662; ENSDARP00000139302; ENSDARG00000103862.
DR   Ensembl; ENSDART00000182028; ENSDARP00000152861; ENSDARG00000103862.
DR   Ensembl; ENSDART00000187604; ENSDARP00000152675; ENSDARG00000103862.
DR   GeneID; 58049; -.
DR   KEGG; dre:58049; -.
DR   CTD; 58049; -.
DR   ZFIN; ZDB-GENE-000823-3; hoxa3a.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000159522; -.
DR   HOGENOM; CLU_051508_1_0_1; -.
DR   InParanoid; Q8AWZ2; -.
DR   OMA; PEYDTHH; -.
DR   OrthoDB; 934469at2759; -.
DR   PhylomeDB; Q8AWZ2; -.
DR   TreeFam; TF315938; -.
DR   PRO; PR:Q8AWZ2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 19.
DR   Bgee; ENSDARG00000103862; Expressed in pharyngeal gill and 49 other tissues.
DR   ExpressionAtlas; Q8AWZ2; baseline.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IDA:ZFIN.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR025281; DUF4074.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF13293; DUF4074; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..410
FT                   /note="Homeobox protein Hox-A3a"
FT                   /id="PRO_0000200046"
FT   DNA_BIND        163..222
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          79..126
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          222..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           127..132
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        79..120
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        154
FT                   /note="D -> RQ (in Ref. 1; AAD15938)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        273..274
FT                   /note="AS -> HL (in Ref. 1; AAD15938)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   410 AA;  44107 MW;  61AEBA565A10F2DC CRC64;
     MQKATYCDGS AIYSGLPYQS ANGLGYDASQ QQYLQALHAE SEYHRPACSL QSPGISAGLH
     TSNEMSEVCQ QINGTQATVT DTSDNKQPPT APSGPSSPSS LNQIPNIDSA AKNPVHVSPT
     PSTRKHIFPW MKESRQNTKQ KSCSIISVES CAGDKSPPGS AASKRARTAY TSAQLVELEK
     EFHFNRYLCR PRRVEMANLL NLTERQIKIW FQNRRMKYKK DQKGLGMMPS PGAQSPHSPV
     SLSSGGGGGG GSAYLSSMHS LVNSVTYDSP SPASYNKPQS NTYSLPTSYP PLNNCPPPQK
     RYQGTGTATP EYDTHHIQGN NNYGTQVQGS PVYVSGGGGY SDSLVGMGAS VFGLTHLPHP
     SQGNIDYNGA ITMGNSHQQG ACDSNPCTFT DLTPHYSQGR IQEAPKLTHL