HXA3_BOVIN
ID HXA3_BOVIN Reviewed; 442 AA.
AC Q08DG7;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Homeobox protein Hox-A3;
GN Name=HOXA3;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Ascending colon;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC123759; AAI23760.1; -; mRNA.
DR RefSeq; NP_001070293.1; NM_001076825.1.
DR AlphaFoldDB; Q08DG7; -.
DR SMR; Q08DG7; -.
DR STRING; 9913.ENSBTAP00000010700; -.
DR PaxDb; Q08DG7; -.
DR Ensembl; ENSBTAT00000010700; ENSBTAP00000010700; ENSBTAG00000008139.
DR Ensembl; ENSBTAT00000067210; ENSBTAP00000072905; ENSBTAG00000008139.
DR Ensembl; ENSBTAT00000068318; ENSBTAP00000065502; ENSBTAG00000008139.
DR GeneID; 509991; -.
DR KEGG; bta:509991; -.
DR CTD; 3200; -.
DR VEuPathDB; HostDB:ENSBTAG00000008139; -.
DR VGNC; VGNC:29911; HOXA3.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000159522; -.
DR HOGENOM; CLU_051508_1_0_1; -.
DR InParanoid; Q08DG7; -.
DR OMA; SHHPSQG; -.
DR OrthoDB; 934469at2759; -.
DR TreeFam; TF315938; -.
DR Proteomes; UP000009136; Chromosome 4.
DR Bgee; ENSBTAG00000008139; Expressed in trachea and 82 other tissues.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0071837; F:HMG box domain binding; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0048645; P:animal organ formation; IEA:Ensembl.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0001974; P:blood vessel remodeling; IEA:Ensembl.
DR GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IBA:GO_Central.
DR GO; GO:0010467; P:gene expression; IEA:Ensembl.
DR GO; GO:0021615; P:glossopharyngeal nerve morphogenesis; IEA:Ensembl.
DR GO; GO:0060017; P:parathyroid gland development; IEA:Ensembl.
DR GO; GO:2000648; P:positive regulation of stem cell proliferation; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0010159; P:specification of animal organ position; IEA:Ensembl.
DR GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl.
DR GO; GO:0048538; P:thymus development; IEA:Ensembl.
DR GO; GO:0030878; P:thyroid gland development; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR025281; DUF4074.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF13293; DUF4074; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..442
FT /note="Homeobox protein Hox-A3"
FT /id="PRO_0000274485"
FT DNA_BIND 191..250
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 73..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 247..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 155..160
FT /note="Antp-type hexapeptide"
FT COMPBIAS 81..128
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..310
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 442 AA; 46280 MW; 1CC8674ED40626EC CRC64;
MQKATYYDSS AIYGGYPYQA ANGFGYNANQ QPYPASTALG ADGEYHRPAC SLQSPANAGS
HPKAHELSEA CLRTLSGPPS QPPVLGEPPL APPPPQAAPP APPQPPAPPQ PPAPTPAAPP
PPSSVSPPQN GSSNPTPASA AKSPLLNSPT VAKQIFPWMK ESRQNTKQKT SGSSSGESCA
GDKSPPGQAS SKRARTAYTS AQLVELEKEF HFNRYLCRPR RVEMANLLNL TERQIKIWFQ
NRRMKYKKDQ KGKGMLTSSG GQSPSRSPVP PGPGSYLNSM HSLVNSVPYE PQSPPPFSKP
PQGAYGLPPA SYPAPLPSCA PPPPQKRYTA AGAGAGGTPD YDPHAHGLQG NGSYGTPHLQ
GSPVFVGGSY VEPMSNSGPP LFGLTHLPHT ASAAMDYGGA GPLGSGHHHG PGPGEPHPTY
TDLTAHHPSQ GRIQEAPKLT HL
