ID   HXA3_CHICK              Reviewed;         413 AA.
AC   O93353; Q7T3J5;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 2.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Homeobox protein Hox-A3;
DE   AltName: Full=Homeobox protein Hox-D3;
GN   Name=HOXA3; Synonyms=HOXD-3, HOXD3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9733103;
RX   DOI=10.1002/(sici)1097-0177(199809)213:1<82::aid-aja8>3.0.co;2-u;
RA   Searcy R.D., Yutzey K.E.;
RT   "Analysis of Hox gene expression during early avian heart development.";
RL   Dev. Dyn. 213:82-91(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Watari-Goshima N., Chisaka O.;
RT   "Hoxa3 is required for branchial nerve development.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; AF067959; AAC19377.1; -; mRNA.
DR   EMBL; AB111110; BAC77105.1; -; mRNA.
DR   RefSeq; NP_989879.1; NM_204548.1.
DR   AlphaFoldDB; O93353; -.
DR   SMR; O93353; -.
DR   STRING; 9031.ENSGALP00000041461; -.
DR   PaxDb; O93353; -.
DR   VEuPathDB; HostDB:geneid_395231; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   HOGENOM; CLU_051508_1_0_1; -.
DR   InParanoid; O93353; -.
DR   OrthoDB; 934469at2759; -.
DR   PhylomeDB; O93353; -.
DR   TreeFam; TF315938; -.
DR   PRO; PR:O93353; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR025281; DUF4074.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF13293; DUF4074; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..413
FT                   /note="Homeobox protein Hox-A3"
FT                   /id="PRO_0000200045"
FT   DNA_BIND        173..232
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          72..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          143..177
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          230..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          374..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           137..142
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        80..108
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        109..131
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        171
FT                   /note="T -> A (in Ref. 1; AAC19377)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   413 AA;  44756 MW;  0D9245BDEA8D44C8 CRC64;
     MQKATYYDSS AIYGAYPYQG ANGFTYNASQ QQYPPSSSLV ETEYHRPACS LQSPGSAVSH
     HKANDISESC MRTLPSQPLQ PPGLTDPQAP PQPPPAPQAQ PPPPSSASPS QNASSNPAPA
     NSTKSPALNS PTVSKQIFPW MKESRQNTKQ KNSSSSSGES CAGDKSPPGQ TSSKRARTAY
     TSAQLVELEK EFHFNRYLCR PRRVEMANLL NLTERQIKIW FQNRRMKYKK DQKGKGMMTS
     SGGQSPSRSP VPPAAGGYLN SMHSLVNSVP YEPQSPPPFN KPHQNTYGIP ASYTAPLNNC
     PPPQKRYTGT AAVTPEYDTH PLQGNGYGNP HIQGSPVYVG GNYVETMTNS GPSIFGLTHL
     SHPPSANMDY SGAGPMGNNH HHGPCDPHPT YTDLTAHHPS QGRIQEAPKL THL