HXA3_MOUSE
ID HXA3_MOUSE Reviewed; 443 AA.
AC P02831; Q4V9Z8; Q61197;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 183.
DE RecName: Full=Homeobox protein Hox-A3;
DE AltName: Full=Homeobox protein Hox-1.5;
DE AltName: Full=Homeobox protein MO-10;
GN Name=Hoxa3; Synonyms=Hox-1.5, Hoxa-3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RA Hofmann M., Boehm T.;
RL Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 54-280.
RC STRAIN=ICR X Swiss Webster;
RX PubMed=8710855; DOI=10.1073/pnas.93.16.8247;
RA Tan D.-P., Shao X., Pu L., Guo V., Nirenberg M.;
RT "Sequence and expression of the murine Hoxd-3 homeobox gene.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:8247-8252(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE OF 185-258.
RA Ruddle F.H., Hart C.P., McGinnis W.;
RT "Structural and functional aspects of the mammalian homeo-box sequences.";
RL Trends Genet. 1:48-51(1985).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 185-258.
RX PubMed=6091896; DOI=10.1016/0092-8674(84)90262-9;
RA McGinnis W., Hart C.P., Gehring W.J., Ruddle F.H.;
RT "Molecular cloning and chromosome mapping of a mouse DNA sequence
RT homologous to homeotic genes of Drosophila.";
RL Cell 38:675-680(1984).
RN [6]
RP DNA-BINDING.
RX PubMed=2879282; DOI=10.1073/pnas.83.24.9532;
RA Fainsod A., Bogarad L.D., Ruusala T., Lubin M., Crothers D.M., Ruddle F.H.;
RT "The homeo domain of a murine protein binds 5' to its own homeo box.";
RL Proc. Natl. Acad. Sci. U.S.A. 83:9532-9536(1986).
RN [7]
RP DEVELOPMENTAL STAGE.
RX PubMed=2444477; DOI=10.1016/0012-1606(87)90465-9;
RA Fainsod A., Awgulewitsch A., Ruddle F.H.;
RT "Expression of the murine homeo box gene Hox 1.5 during embryogenesis.";
RL Dev. Biol. 124:125-133(1987).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. Binds 5' to its
CC own homeobox.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: Expressed in a spatially restricted manner in
CC embryos 8.5 dpc, expression is limited to the CNS with an anterior
CC boundary in the hindbrain and extending posteriorly through caudal
CC regions of the spinal cord. The same spatial expression is seen in
CC embryos 9.5 to 12.5 dpc. {ECO:0000269|PubMed:2444477}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; Y11717; CAA72404.1; -; mRNA.
DR EMBL; BC096612; AAH96612.1; -; mRNA.
DR EMBL; U56399; AAC52778.1; -; mRNA.
DR EMBL; K02591; AAA37822.1; -; Genomic_DNA.
DR CCDS; CCDS20140.1; -.
DR PIR; I49746; I49746.
DR RefSeq; NP_034582.1; NM_010452.3.
DR RefSeq; XP_011239527.1; XM_011241225.2.
DR RefSeq; XP_017176891.1; XM_017321402.1.
DR RefSeq; XP_017176892.1; XM_017321403.1.
DR RefSeq; XP_017176893.1; XM_017321404.1.
DR AlphaFoldDB; P02831; -.
DR SMR; P02831; -.
DR BioGRID; 200368; 1.
DR STRING; 10090.ENSMUSP00000110077; -.
DR iPTMnet; P02831; -.
DR PhosphoSitePlus; P02831; -.
DR MaxQB; P02831; -.
DR PaxDb; P02831; -.
DR PRIDE; P02831; -.
DR Antibodypedia; 12366; 204 antibodies from 23 providers.
DR DNASU; 15400; -.
DR Ensembl; ENSMUST00000114434; ENSMUSP00000110077; ENSMUSG00000079560.
DR GeneID; 15400; -.
DR KEGG; mmu:15400; -.
DR UCSC; uc009bya.2; mouse.
DR CTD; 3200; -.
DR MGI; MGI:96175; Hoxa3.
DR VEuPathDB; HostDB:ENSMUSG00000079560; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000159522; -.
DR HOGENOM; CLU_051508_1_0_1; -.
DR InParanoid; P02831; -.
DR OMA; SHHPSQG; -.
DR OrthoDB; 934469at2759; -.
DR PhylomeDB; P02831; -.
DR TreeFam; TF315938; -.
DR BioGRID-ORCS; 15400; 6 hits in 73 CRISPR screens.
DR ChiTaRS; Hoxa3; mouse.
DR PRO; PR:P02831; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P02831; protein.
DR Bgee; ENSMUSG00000079560; Expressed in ascending aorta and 154 other tissues.
DR ExpressionAtlas; P02831; baseline and differential.
DR Genevisible; P02831; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0071837; F:HMG box domain binding; IPI:UniProtKB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0048645; P:animal organ formation; IMP:MGI.
DR GO; GO:0009887; P:animal organ morphogenesis; IMP:MGI.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
DR GO; GO:0001974; P:blood vessel remodeling; IMP:MGI.
DR GO; GO:0051216; P:cartilage development; IGI:MGI.
DR GO; GO:0008283; P:cell population proliferation; IMP:MGI.
DR GO; GO:0048706; P:embryonic skeletal system development; IGI:MGI.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IGI:MGI.
DR GO; GO:0010467; P:gene expression; IMP:MGI.
DR GO; GO:0021615; P:glossopharyngeal nerve morphogenesis; IMP:MGI.
DR GO; GO:0060017; P:parathyroid gland development; IGI:MGI.
DR GO; GO:2000648; P:positive regulation of stem cell proliferation; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0010159; P:specification of animal organ position; IGI:MGI.
DR GO; GO:0072089; P:stem cell proliferation; IMP:MGI.
DR GO; GO:0048538; P:thymus development; IMP:MGI.
DR GO; GO:0030878; P:thyroid gland development; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR025281; DUF4074.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF13293; DUF4074; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..443
FT /note="Homeobox protein Hox-A3"
FT /id="PRO_0000200044"
FT DNA_BIND 192..251
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 74..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 163..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 401..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 156..161
FT /note="Antp-type hexapeptide"
FT COMPBIAS 82..129
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..329
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 185
FT /note="S -> G (in Ref. 4 and 5)"
FT /evidence="ECO:0000305"
FT CONFLICT 195
FT /note="A -> G (in Ref. 4 and 5)"
FT /evidence="ECO:0000305"
FT CONFLICT 201..202
FT /note="SA -> RP (in Ref. 4 and 5)"
FT /evidence="ECO:0000305"
FT CONFLICT 218
FT /note="C -> M (in Ref. 4 and 5)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 443 AA; 46430 MW; 6C0E184B0F6F2D40 CRC64;
MQKATYYDSS AIYGGYPYQA ANGFAYNASQ QPYAPSAALG TDGVEYHRPA CSLQSPASAG
GHPKTHELSE ACLRTLSGPP SQPPGLGEPP LPPPPPQAAP PAPQPPQPPP QPPAPTPAAP
PPPSSVSPPQ SANSNPTPAS TAKSPLLNSP TVGKQIFPWM KESRQNTKQK TSGSSSGESC
AGDKSPPGQA SSKRARTAYT SAQLVELEKE FHFNRYLCRP RRVEMANLLN LTERQIKIWF
QNRRMKYKKD QKGKGMLTSS GGQSPSRSPV PPGAGGYLNS MHSLVNSVPY EPQSPPPFSK
PPQGAYGLPP ASYPAPLPSC APPPPPQKRY TAAGSGAGGT PDYDPHAHGL QGNGSYGTPH
LQGSPVFVGG SYVEPMSNSG PLFGLTHLPH TTSAAMDYGG TGPLGSGHHH GPGPGEPHPT
YTDLTAHHPS QGRIQEAPKL THL
