ID   HXA4_CHICK              Reviewed;         309 AA.
AC   P17277;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   03-AUG-2022, entry version 155.
DE   RecName: Full=Homeobox protein Hox-A4;
DE   AltName: Full=Homeobox protein Hox-1.4;
DE            Short=Chox-1.4;
GN   Name=HOXA4; Synonyms=CHOX-1.4;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1970866; DOI=10.1093/nar/18.7.1739;
RA   Sasaki H., Yokoyama E., Kuroiwa A.;
RT   "Specific DNA binding of the two chicken Deformed family homeodomain
RT   proteins, Chox-1.4 and Chox-a.";
RL   Nucleic Acids Res. 18:1739-1747(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 207-273.
RC   STRAIN=Comet Hubbard hybrid;
RX   PubMed=1973835; DOI=10.1093/nar/18.13.3999;
RA   Scotting P.J., Hewitt M., Keynes R.J.;
RT   "Isolation and analysis of chick homeobox cDNA clones.";
RL   Nucleic Acids Res. 18:3999-3999(1990).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. Binds to sites in
CC       the 5'-flanking sequence of its coding region with various affinities.
CC       The consensus sequences of the high and low affinity binding sites are
CC       5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DOMAIN: The proline stretch works as a part of the transcriptional
CC       activation domain.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. Deformed subfamily.
CC       {ECO:0000305}.
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DR   EMBL; X52670; CAA36896.1; -; mRNA.
DR   EMBL; X52747; CAB57949.1; -; mRNA.
DR   PIR; S09257; S09257.
DR   RefSeq; NP_001025517.1; NM_001030346.1.
DR   AlphaFoldDB; P17277; -.
DR   SMR; P17277; -.
DR   STRING; 9031.ENSGALP00000029207; -.
DR   PaxDb; P17277; -.
DR   GeneID; 395307; -.
DR   KEGG; gga:395307; -.
DR   CTD; 3201; -.
DR   VEuPathDB; HostDB:geneid_395307; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   HOGENOM; CLU_061398_0_0_1; -.
DR   InParanoid; P17277; -.
DR   OrthoDB; 1154159at2759; -.
DR   PRO; PR:P17277; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..309
FT                   /note="Homeobox protein Hox-A4"
FT                   /id="PRO_0000200052"
FT   DNA_BIND        209..268
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          17..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          267..309
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           188..193
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        40..71
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        78..99
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..142
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        274..293
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   309 AA;  33478 MW;  8898A41502319341 CRC64;
     MTMSSFLINS NYIEPKFPPC EEYTQHSGSA GSSASYHPHH PHPHAPPPPP PPPPPHLHAA
     HPGPALPEYF PRPRREPGYQ APAAPPGPPG PPPEALYPAQ APSYPQAPYS YSSAGSAAPG
     PEQPPPGASP PPPPPAKGHP GPAQPLLPGH ALQRRCEAAP AAGAGTGPGC ALLPDKSLPG
     LKGKEPVVYP WMKKIHVSTV NPNYSGGEPK RSRTAYTRQQ VLELEKEFHF NRYLTRRRRI
     EIAHTLCLSE RQVKIWFQNR RMKWKKDHKL PNTKMRSSNQ PSLGQQQAKA QTQGHPRPLD
     GAAPNAAAL