ID   HXA4_LINSA              Reviewed;          80 AA.
AC   P81192;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Homeobox protein Hox-A4;
DE   AltName: Full=LsHox 4;
DE   Flags: Fragment;
GN   Name=HOXA4;
OS   Lineus sanguineus (Ribbon worm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Nemertea; Pilidiophora;
OC   Heteronemertea; Lineidae; Lineus.
OX   NCBI_TaxID=187800;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=9501210; DOI=10.1073/pnas.95.6.3030;
RA   Kmita-Cunisse M., Loosli F., Bierne J., Gehring W.J.;
RT   "Homeobox genes in the ribbonworm Lineus sanguineus: evolutionary
RT   implications.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:3030-3035(1998).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. Deformed subfamily.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P81192; -.
DR   SMR; P81192; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           <1..>80
FT                   /note="Homeobox protein Hox-A4"
FT                   /id="PRO_0000200056"
FT   DNA_BIND        21..80
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   NON_TER         1
FT   NON_TER         80
SQ   SEQUENCE   80 AA;  9860 MW;  F2CE1B01CB8042F1 CRC64;
     AANGNFNGSE SKRSRTAYTR HQILELEKEF HFNRYLTRRR RIEIAHALDL SERQIKIWFQ
     NRRMKWKKEH KLPNTKLRLP