ID   HXA4_RAT                Reviewed;          67 AA.
AC   P09635;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 130.
DE   RecName: Full=Homeobox protein Hox-A4;
DE   AltName: Full=Homeobox protein R2;
DE   Flags: Fragment;
GN   Name=Hoxa4; Synonyms=Hox-a4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=2886401; DOI=10.1016/0378-1119(87)90343-x;
RA   Falzon M., Sanderson N., Chung S.Y.;
RT   "Cloning and expression of rat homeo-box-containing sequences.";
RL   Gene 54:23-32(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42.
RX   PubMed=7702549; DOI=10.1007/bf02426897;
RA   Sakoyama Y., Mizuta I., Ogasawara N., Yoshikawa H.;
RT   "Cloning of rat homeobox genes.";
RL   Biochem. Genet. 32:351-360(1994).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. Deformed subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M16808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; S76296; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; B27471; B27471.
DR   AlphaFoldDB; P09635; -.
DR   SMR; P09635; -.
DR   STRING; 10116.ENSRNOP00000035732; -.
DR   PaxDb; P09635; -.
DR   RGD; 2814; Hoxa4.
DR   eggNOG; KOG0489; Eukaryota.
DR   InParanoid; P09635; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; ISO:RGD.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; ISO:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           <1..>67
FT                   /note="Homeobox protein Hox-A4"
FT                   /id="PRO_0000200050"
FT   DNA_BIND        <1..42
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   NON_TER         1
FT   NON_TER         67
SQ   SEQUENCE   67 AA;  8346 MW;  5BFDFEAE93193780 CRC64;
     EFHFNRYLTR RRRIEIAHTL CLSERQVKIW FQNRRMKWKK DHKLPNTRCD LPTLPRPLPA
     RLGKHKL