HXA5_CHICK
ID HXA5_CHICK Reviewed; 270 AA.
AC Q6B3N0;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Homeobox protein Hox-A5;
GN Name=HOXA5;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Oberg K.C., Pira C.U., Creamer D.H., Revelli J.-P., Eichele G.;
RT "Expression and regulation of HOXA5, HOXA6 and HOXA7 during chick wing
RT development.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. Also binds to its
CC own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; AY686640; AAT90845.1; -; mRNA.
DR RefSeq; NP_001305348.1; NM_001318419.1.
DR AlphaFoldDB; Q6B3N0; -.
DR SMR; Q6B3N0; -.
DR STRING; 9031.ENSGALP00000041319; -.
DR Ensembl; ENSGALT00000045692; ENSGALP00000043005; ENSGALG00000025929.
DR GeneID; 100858404; -.
DR KEGG; gga:100858404; -.
DR CTD; 3202; -.
DR VEuPathDB; HostDB:geneid_100858404; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000159894; -.
DR HOGENOM; CLU_061398_2_1_1; -.
DR InParanoid; Q6B3N0; -.
DR OMA; HNYGEHN; -.
DR OrthoDB; 980936at2759; -.
DR PhylomeDB; Q6B3N0; -.
DR PRO; PR:Q6B3N0; -.
DR Proteomes; UP000000539; Chromosome 2.
DR Bgee; ENSGALG00000025929; Expressed in lung and 9 other tissues.
DR ExpressionAtlas; Q6B3N0; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0060435; P:bronchiole development; IEA:Ensembl.
DR GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Ensembl.
DR GO; GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IEA:Ensembl.
DR GO; GO:0060574; P:intestinal epithelial cell maturation; IEA:Ensembl.
DR GO; GO:0048286; P:lung alveolus development; IEA:Ensembl.
DR GO; GO:0060480; P:lung goblet cell differentiation; IEA:Ensembl.
DR GO; GO:0060484; P:lung-associated mesenchyme development; IEA:Ensembl.
DR GO; GO:0060638; P:mesenchymal-epithelial cell signaling; IEA:Ensembl.
DR GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0045647; P:negative regulation of erythrocyte differentiation; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0045639; P:positive regulation of myeloid cell differentiation; IEA:Ensembl.
DR GO; GO:0033599; P:regulation of mammary gland epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0003016; P:respiratory system process; IEA:Ensembl.
DR GO; GO:0030878; P:thyroid gland development; IEA:Ensembl.
DR GO; GO:0060535; P:trachea cartilage morphogenesis; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017995; Homeobox_antennapedia.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00025; ANTENNAPEDIA.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..270
FT /note="Homeobox protein Hox-A5"
FT /id="PRO_0000200061"
FT DNA_BIND 195..254
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 67..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 176..181
FT /note="Antp-type hexapeptide"
FT COMPBIAS 67..94
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 270 AA; 29742 MW; 1A9F8EC9E740B1CC CRC64;
MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQYRDSASM HSGRYGYGYN GMDLSVGRSA
STHFGASERA RTYPANSTSA STEPRYSQSA AASHSPPPDP LPCTAVAASP VSESHHGVKN
SLGNSSSTSS NSSSSTHISR DGVGTSSGTE EDTPASSEQA SAPSDQSTAQ PSQPQIYPWM
RKLHISHDNI GGPEGKRART AYTRYQTLEL EKEFHFNRYL TRRRRIEIAH ALCLSERQIK
IWFQNRRMKW KKDNKLKSMS MAAAGGAFRP
