ID   HXA5_LEMCA              Reviewed;         270 AA.
AC   A2D5Y4;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Homeobox protein Hox-A5;
GN   Name=HOXA5;
OS   Lemur catta (Ring-tailed lemur).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Lemuridae; Lemur.
OX   NCBI_TaxID=9447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.;
RT   "Positive selection in transcription factor genes on the human lineage.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. Also binds to its
CC       own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms a DNA-binding heterodimer with transcription factor
CC       PBX1. {ECO:0000250|UniProtKB:P20719}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; DQ976822; ABM68948.1; -; Genomic_DNA.
DR   AlphaFoldDB; A2D5Y4; -.
DR   SMR; A2D5Y4; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..270
FT                   /note="Homeobox protein Hox-A5"
FT                   /id="PRO_0000285419"
FT   DNA_BIND        195..254
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          60..175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           176..181
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        91..105
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        114..142
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        152..166
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   270 AA;  29297 MW;  EB83C065FA0D3B07 CRC64;
     MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQFRDSASM HSGRYGYGYN GMDLSVGRSG
     SGHFGSGERA RSYAAGATTA PAEPRYSQPA TSTHSPPPDP LPCSAVAPSP GSDSHHGGKN
     SLGNSSGASA NAGSTHISSR EGVGTASGAE EDAPASSEQA SAQSEPSPAP PAQPQIYPWM
     RKLHISHDNI GGPEGKRART AYTRYQTLEL EKEFHFNRYL TRRRRIEIAH ALCLSERQIK
     IWFQNRRMKW KKDNKLKSMS MAAAGGAFRP