HXA5_MOUSE
ID HXA5_MOUSE Reviewed; 270 AA.
AC P09021; Q91VQ5;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1988, sequence version 1.
DT 03-AUG-2022, entry version 177.
DE RecName: Full=Homeobox protein Hox-A5;
DE AltName: Full=Homeobox protein Hox-1.3;
DE AltName: Full=Homeobox protein M2;
GN Name=Hoxa5; Synonyms=Hox-1.3, Hoxa-5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=2890554; DOI=10.1101/gad.1.5.482;
RA Odenwald W.F., Taylor C.F., Palmer-Hill F.J., Friedrich V. Jr., Tani M.,
RA Lazzarini R.A.;
RT "Expression of a homeo domain protein in noncontact-inhibited cultured
RT cells and postmitotic neurons.";
RL Genes Dev. 1:482-496(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=2901335; DOI=10.1242/dev.102.2.349;
RA Fibi M., Zink B., Kessel M., Colberg-Poley A.M., Labeit S., Lehrach H.,
RA Gruss P.;
RT "Coding sequence and expression of the homeobox gene Hox 1.3.";
RL Development 102:349-359(1988).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP DNA-BINDING SPECIFICITY.
RX PubMed=2565857; DOI=10.1101/gad.3.2.158;
RA Odenwald W.F., Garbern J., Arnheiter H., Tournier-Lasserve E.,
RA Lazzarini R.A.;
RT "The Hox-1.3 homeo box protein is a sequence-specific DNA-binding
RT phosphoprotein.";
RL Genes Dev. 3:158-172(1989).
RN [5]
RP INTERACTION WITH PBX1.
RX PubMed=7791786; DOI=10.1128/mcb.15.7.3786;
RA Lu Q., Knoepfler P.S., Scheele J., Wright D.D., Kamps M.P.;
RT "Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the
RT products of multiple murine Hox genes, some of which are themselves
RT oncogenes.";
RL Mol. Cell. Biol. 15:3786-3795(1995).
RN [6]
RP CHARACTERIZATION.
RX PubMed=8635464; DOI=10.1002/j.1460-2075.1996.tb00473.x;
RA Zhao J.J., Lazzarini R.A., Pick L.;
RT "Functional dissection of the mouse Hox-a5 gene.";
RL EMBO J. 15:1313-1322(1996).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. Also binds to its
CC own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.
CC -!- SUBUNIT: Forms a DNA-binding heterodimer with transcription factor
CC PBX1. {ECO:0000269|PubMed:7791786}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: Expressed during embryogenesis and in adult
CC kidney.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; M36604; AAA37838.1; -; mRNA.
DR EMBL; Y00208; CAA68364.1; -; Genomic_DNA.
DR EMBL; X16840; CAA34738.1; -; mRNA.
DR EMBL; M28021; AAA37837.1; -; mRNA.
DR EMBL; BC011063; AAH11063.1; -; mRNA.
DR CCDS; CCDS20143.1; -.
DR PIR; S07812; WJMS13.
DR RefSeq; NP_034583.1; NM_010453.5.
DR AlphaFoldDB; P09021; -.
DR SMR; P09021; -.
DR BioGRID; 200370; 8.
DR IntAct; P09021; 3.
DR STRING; 10090.ENSMUSP00000039012; -.
DR PhosphoSitePlus; P09021; -.
DR MaxQB; P09021; -.
DR PaxDb; P09021; -.
DR PeptideAtlas; P09021; -.
DR PRIDE; P09021; -.
DR ProteomicsDB; 266925; -.
DR Antibodypedia; 25931; 464 antibodies from 33 providers.
DR DNASU; 15402; -.
DR Ensembl; ENSMUST00000048794; ENSMUSP00000039012; ENSMUSG00000038253.
DR GeneID; 15402; -.
DR KEGG; mmu:15402; -.
DR UCSC; uc009byh.1; mouse.
DR CTD; 3202; -.
DR MGI; MGI:96177; Hoxa5.
DR VEuPathDB; HostDB:ENSMUSG00000038253; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000159894; -.
DR HOGENOM; CLU_061398_2_0_1; -.
DR InParanoid; P09021; -.
DR OMA; HNYGEHN; -.
DR OrthoDB; 980936at2759; -.
DR PhylomeDB; P09021; -.
DR TreeFam; TF316310; -.
DR BioGRID-ORCS; 15402; 1 hit in 72 CRISPR screens.
DR PRO; PR:P09021; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P09021; protein.
DR Bgee; ENSMUSG00000038253; Expressed in postcranial axial skeleton and 168 other tissues.
DR Genevisible; P09021; MM.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0003677; F:DNA binding; IDA:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
DR GO; GO:0060435; P:bronchiole development; IMP:MGI.
DR GO; GO:0060536; P:cartilage morphogenesis; IMP:MGI.
DR GO; GO:0016477; P:cell migration; IMP:MGI.
DR GO; GO:0060764; P:cell-cell signaling involved in mammary gland development; IMP:MGI.
DR GO; GO:0048706; P:embryonic skeletal system development; IGI:MGI.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IMP:MGI.
DR GO; GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IMP:MGI.
DR GO; GO:0060574; P:intestinal epithelial cell maturation; IMP:MGI.
DR GO; GO:0060481; P:lobar bronchus epithelium development; IMP:MGI.
DR GO; GO:0048286; P:lung alveolus development; IMP:MGI.
DR GO; GO:0030324; P:lung development; IMP:MGI.
DR GO; GO:0060480; P:lung goblet cell differentiation; IMP:MGI.
DR GO; GO:0060484; P:lung-associated mesenchyme development; IMP:MGI.
DR GO; GO:0060749; P:mammary gland alveolus development; IMP:MGI.
DR GO; GO:0060644; P:mammary gland epithelial cell differentiation; IMP:MGI.
DR GO; GO:0060638; P:mesenchymal-epithelial cell signaling; IMP:MGI.
DR GO; GO:0002009; P:morphogenesis of an epithelium; IMP:MGI.
DR GO; GO:0035264; P:multicellular organism growth; IMP:MGI.
DR GO; GO:0016525; P:negative regulation of angiogenesis; ISO:MGI.
DR GO; GO:0045647; P:negative regulation of erythrocyte differentiation; ISO:MGI.
DR GO; GO:0007389; P:pattern specification process; IMP:MGI.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
DR GO; GO:0045639; P:positive regulation of myeloid cell differentiation; ISO:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0033599; P:regulation of mammary gland epithelial cell proliferation; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; IMP:MGI.
DR GO; GO:0003016; P:respiratory system process; IMP:MGI.
DR GO; GO:0001501; P:skeletal system development; IMP:MGI.
DR GO; GO:0030878; P:thyroid gland development; IMP:MGI.
DR GO; GO:0060535; P:trachea cartilage morphogenesis; IMP:MGI.
DR GO; GO:0060439; P:trachea morphogenesis; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017995; Homeobox_antennapedia.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00025; ANTENNAPEDIA.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..270
FT /note="Homeobox protein Hox-A5"
FT /id="PRO_0000200058"
FT DNA_BIND 195..254
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 75..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 176..181
FT /note="Antp-type hexapeptide"
FT COMPBIAS 91..105
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 70
FT /note="A -> V (in Ref. 3; AAH11063)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 270 AA; 29237 MW; DC4BDDA8FE62766E CRC64;
MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQFRDSASM HSGRYGYGYN GMDLSVGRSG
SGHFGSGERA RSYAAGASAA PAEPRYSQPA TSTHSPPPDP LPCSAVAPSP GSDSHHGGKN
SLGNSSGASA NAGSTHISSR EGVGTASAAE EDAPASSEQA GAQSEPSPAP PAQPQIYPWM
RKLHISHDNI GGPEGKRART AYTRYQTLEL EKEFHFNRYL TRRRRIEIAH ALCLSERQIK
IWFQNRRMKW KKDNKLKSMS MAAAGGAFRP
