HXA5_RAT
ID HXA5_RAT Reviewed; 233 AA.
AC P52949;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 132.
DE RecName: Full=Homeobox protein Hox-A5;
DE AltName: Full=Homeobox protein Hox-1.3;
DE Flags: Fragment;
GN Name=Hoxa5; Synonyms=Hox-1.3, Hoxa-5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Aorta;
RX PubMed=7915120;
RA Gorski D.H., LePage D.F., Walsh K.;
RT "Cloning and sequence analysis of homeobox transcription factor cDNAs with
RT an inosine-containing probe.";
RL BioTechniques 16:856-858(1994).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. Also binds to its
CC own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Forms a DNA-binding heterodimer with transcription factor
CC PBX1. {ECO:0000250|UniProtKB:P20719}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; L03556; AAA67844.1; -; mRNA.
DR PIR; I65197; I65197.
DR PaxDb; P52949; -.
DR PRIDE; P52949; -.
DR RGD; 620609; Hoxa5.
DR eggNOG; KOG0489; Eukaryota.
DR InParanoid; P52949; -.
DR PhylomeDB; P52949; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0003677; F:DNA binding; ISO:RGD.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0009952; P:anterior/posterior pattern specification; ISO:RGD.
DR GO; GO:0060435; P:bronchiole development; ISO:RGD.
DR GO; GO:0060536; P:cartilage morphogenesis; ISO:RGD.
DR GO; GO:0016477; P:cell migration; ISO:RGD.
DR GO; GO:0060764; P:cell-cell signaling involved in mammary gland development; ISO:RGD.
DR GO; GO:0048706; P:embryonic skeletal system development; ISO:RGD.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; ISO:RGD.
DR GO; GO:0060441; P:epithelial tube branching involved in lung morphogenesis; ISO:RGD.
DR GO; GO:0060574; P:intestinal epithelial cell maturation; ISO:RGD.
DR GO; GO:0060481; P:lobar bronchus epithelium development; ISO:RGD.
DR GO; GO:0048286; P:lung alveolus development; ISO:RGD.
DR GO; GO:0030324; P:lung development; ISO:RGD.
DR GO; GO:0060480; P:lung goblet cell differentiation; ISO:RGD.
DR GO; GO:0060484; P:lung-associated mesenchyme development; ISO:RGD.
DR GO; GO:0060749; P:mammary gland alveolus development; ISO:RGD.
DR GO; GO:0060644; P:mammary gland epithelial cell differentiation; ISO:RGD.
DR GO; GO:0060638; P:mesenchymal-epithelial cell signaling; ISO:RGD.
DR GO; GO:0002009; P:morphogenesis of an epithelium; ISO:RGD.
DR GO; GO:0035264; P:multicellular organism growth; ISO:RGD.
DR GO; GO:0016525; P:negative regulation of angiogenesis; ISO:RGD.
DR GO; GO:0045647; P:negative regulation of erythrocyte differentiation; ISO:RGD.
DR GO; GO:0007389; P:pattern specification process; ISO:RGD.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISO:RGD.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR GO; GO:0045639; P:positive regulation of myeloid cell differentiation; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0033599; P:regulation of mammary gland epithelial cell proliferation; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; ISO:RGD.
DR GO; GO:0003016; P:respiratory system process; ISO:RGD.
DR GO; GO:0001501; P:skeletal system development; ISO:RGD.
DR GO; GO:0030878; P:thyroid gland development; ISO:RGD.
DR GO; GO:0060535; P:trachea cartilage morphogenesis; ISO:RGD.
DR GO; GO:0060439; P:trachea morphogenesis; ISO:RGD.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017995; Homeobox_antennapedia.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00025; ANTENNAPEDIA.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN <1..>233
FT /note="Homeobox protein Hox-A5"
FT /id="PRO_0000200059"
FT DNA_BIND 174..233
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 155..160
FT /note="Antp-type hexapeptide"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..84
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT NON_TER 233
SQ SEQUENCE 233 AA; 25391 MW; 0937608EEDAF368C CRC64;
HNYGDHSSVS EQFRDSASMH SGRYGYGYNG MDLSVGRSGS GHFGSGEXXR SYXAGASAAP
AEPRYSQPAT STHSPPPDPL PCSAVAPLPG SDTHHGGKNS LGNSSGCSAN CGSTHISSRE
GVGTASAAEE DAPASSEQAG AQSEPSPAPP AQPQIYPWMR KLHISHDNIG GPEGKRARTC
YTRYQTLELE KEFHFNRYLT RRRRIEIAHA LCLSERQIKI WFQNRRMKWK KDK
