ID   HXA5_SHEEP              Reviewed;          49 AA.
AC   Q28599;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Homeobox protein Hox-A5;
DE   Flags: Fragment;
GN   Name=HOXA5; Synonyms=HOXA-5;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Roche P.J.;
RL   Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. Also binds to its
CC       own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms a DNA-binding heterodimer with transcription factor
CC       PBX1. {ECO:0000250|UniProtKB:P20719}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; U61978; AAB04754.1; -; mRNA.
DR   AlphaFoldDB; Q28599; -.
DR   SMR; Q28599; -.
DR   STRING; 9940.ENSOARP00000007539; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           <1..>49
FT                   /note="Homeobox protein Hox-A5"
FT                   /id="PRO_0000200060"
FT   DNA_BIND        <1..49
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   NON_TER         1
FT   NON_TER         49
SQ   SEQUENCE   49 AA;  6331 MW;  1EE702315E7C099B CRC64;
     QTLELEKEFH FNRYLTRRRR IEIAHALCLS ERQIKIWFQN RRMKWKKDN