ID   HXA6_CHICK              Reviewed;         231 AA.
AC   Q5YLH5;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Homeobox protein Hox-A6;
GN   Name=HOXA6;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Oberg K.C., Pira C.U., Caltharp S.A., Naruse T., Eichele G., Brunick L.,
RA   Burke A.C.;
RT   "Expression and regulation of Hoxa5-7 during chick wing specification and
RT   outgrowth.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; AY307380; AAQ81318.1; -; mRNA.
DR   RefSeq; NP_001026158.1; NM_001030987.1.
DR   AlphaFoldDB; Q5YLH5; -.
DR   SMR; Q5YLH5; -.
DR   STRING; 9031.ENSGALP00000042068; -.
DR   Ensembl; ENSGALT00000043274; ENSGALP00000042068; ENSGALG00000028908.
DR   GeneID; 420630; -.
DR   KEGG; gga:420630; -.
DR   CTD; 3203; -.
DR   VEuPathDB; HostDB:geneid_420630; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000161585; -.
DR   HOGENOM; CLU_061398_1_1_1; -.
DR   InParanoid; Q5YLH5; -.
DR   OMA; HGDYLHF; -.
DR   OrthoDB; 1186205at2759; -.
DR   PhylomeDB; Q5YLH5; -.
DR   PRO; PR:Q5YLH5; -.
DR   Proteomes; UP000000539; Chromosome 2.
DR   Bgee; ENSGALG00000028908; Expressed in muscle tissue and 7 other tissues.
DR   GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0048706; P:embryonic skeletal system development; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..231
FT                   /note="Homeobox protein Hox-A6"
FT                   /id="PRO_0000200069"
FT   DNA_BIND        153..212
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          212..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           134..139
FT                   /note="Antp-type hexapeptide"
SQ   SEQUENCE   231 AA;  26510 MW;  437DB6474C74C7FD CRC64;
     MSSYFVNPTF PGSLPAGQDS FLGQIPLYPA GYDALRHFPT SYGASSLQDK TYTSPCFYQQ
     SNTVIACNRA SYEYGASCFY SDKEISSASP SGSGKQRGQG DYLHFSPEQQ YKSNGVQSKI
     VNDEGTDRKY TSPVYPWMQR MNSCAGTVYG AHGRRGRQTY TRYQTLELEK EFHFNRYLTR
     RRRIEIANAL CLTERQIKIW FQNRRMKWKK ENKFINSTQP GSDETEEKSG E