HXA6_MOUSE
ID HXA6_MOUSE Reviewed; 232 AA.
AC P09092; Q9JI98;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 2.
DT 03-AUG-2022, entry version 176.
DE RecName: Full=Homeobox protein Hox-A6;
DE AltName: Full=Homeobox protein Hox-1.2;
DE AltName: Full=Homeobox protein M5-4;
GN Name=Hoxa6; Synonyms=Hox-1.2, Hoxa-6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ICR X Swiss Webster; TISSUE=Liver;
RA Tan D.P., Shao X., Peterkofsky A.;
RT "Mouse Hoxa6 gene structure and regulation.";
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 136-232.
RX PubMed=2416462; DOI=10.1016/0092-8674(85)90010-8;
RA Colberg-Poley A.M., Voss S.D., Chowdhury K., Stewart C.L., Wagner E.F.,
RA Gruss P.;
RT "Clustered homeo boxes are differentially expressed during murine
RT development.";
RL Cell 43:39-45(1985).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; AF247663; AAF97512.1; -; Genomic_DNA.
DR EMBL; M11988; AAA37830.1; -; Genomic_DNA.
DR CCDS; CCDS20144.1; -.
DR PIR; A24779; A24779.
DR RefSeq; NP_034584.1; NM_010454.1.
DR AlphaFoldDB; P09092; -.
DR SMR; P09092; -.
DR BioGRID; 200371; 6.
DR IntAct; P09092; 6.
DR STRING; 10090.ENSMUSP00000058755; -.
DR PhosphoSitePlus; P09092; -.
DR PaxDb; P09092; -.
DR PRIDE; P09092; -.
DR ProteomicsDB; 273058; -.
DR Antibodypedia; 1430; 258 antibodies from 29 providers.
DR DNASU; 15403; -.
DR Ensembl; ENSMUST00000062829; ENSMUSP00000058755; ENSMUSG00000043219.
DR GeneID; 15403; -.
DR KEGG; mmu:15403; -.
DR UCSC; uc009byi.1; mouse.
DR CTD; 3203; -.
DR MGI; MGI:96178; Hoxa6.
DR VEuPathDB; HostDB:ENSMUSG00000043219; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000161585; -.
DR HOGENOM; CLU_061398_1_1_1; -.
DR InParanoid; P09092; -.
DR OMA; HGDYLHF; -.
DR OrthoDB; 1186205at2759; -.
DR PhylomeDB; P09092; -.
DR TreeFam; TF316310; -.
DR BioGRID-ORCS; 15403; 3 hits in 70 CRISPR screens.
DR PRO; PR:P09092; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P09092; protein.
DR Bgee; ENSMUSG00000043219; Expressed in embryonic post-anal tail and 72 other tissues.
DR ExpressionAtlas; P09092; baseline and differential.
DR GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
DR GO; GO:0048706; P:embryonic skeletal system development; IGI:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017995; Homeobox_antennapedia.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00025; ANTENNAPEDIA.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..232
FT /note="Homeobox protein Hox-A6"
FT /id="PRO_0000200068"
FT DNA_BIND 154..213
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 88..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 135..140
FT /note="Antp-type hexapeptide"
FT CONFLICT 136..146
FT /note="YPWMQRMNSCA -> ASLIRTSFLPT (in Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 232 AA; 26335 MW; 7E29499428BBA8A7 CRC64;
MSSYFVNPTF PGSLPSGQDS FLGQLPLYPA GYDALRPFPA SYGASSLPDK TYTSPCFYQQ
SNSVLACNRA SYEYGASCFY SDKDLSGASP SGNNKQRGPG DYLHFSPEQQ YKPDGSVQGK
ALHEEGTDRK YTSPVYPWMQ RMNSCAGAVY GSHGRRGRQT YTRYQTLELE KEFHFNRYLT
RRRRIEIANA LCLTERQIKI WFQNRRMKWK KENKLINSTQ ASGEDSEAKA GE
