ID   HXA7_CHICK              Reviewed;         219 AA.
AC   Q90VZ9;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Homeobox protein Hox-A7;
GN   Name=HOXA7; Synonyms=HOXA-7;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11357191; DOI=10.1002/dvdy.1122;
RA   Gaunt S.J.;
RT   "Gradients and forward spreading of vertebrate Hox gene expression detected
RT   using a Hox/lacZ transgene.";
RL   Dev. Dyn. 221:26-36(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Oberg K.C., Pira C.U., Creamer D.H., Revelli J.-P., Eichele G.;
RT   "Expression and regulation of HOXA5, HOXA6 and HOXA7 during chick wing
RT   development.";
RL   Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; AJ291729; CAC37629.1; -; Genomic_DNA.
DR   EMBL; AF408695; AAL01899.1; -; mRNA.
DR   RefSeq; NP_989926.1; NM_204595.1.
DR   RefSeq; XP_015136767.1; XM_015281281.1.
DR   AlphaFoldDB; Q90VZ9; -.
DR   BMRB; Q90VZ9; -.
DR   SMR; Q90VZ9; -.
DR   STRING; 9031.ENSGALP00000017991; -.
DR   PaxDb; Q90VZ9; -.
DR   Ensembl; ENSGALT00000089091; ENSGALP00000060910; ENSGALG00000026989.
DR   GeneID; 395290; -.
DR   KEGG; gga:395290; -.
DR   CTD; 3204; -.
DR   VEuPathDB; HostDB:geneid_395290; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000161013; -.
DR   HOGENOM; CLU_061398_1_1_1; -.
DR   InParanoid; Q90VZ9; -.
DR   OMA; HKDEGPT; -.
DR   PhylomeDB; Q90VZ9; -.
DR   PRO; PR:Q90VZ9; -.
DR   Proteomes; UP000000539; Chromosome 2.
DR   Bgee; ENSGALG00000026989; Expressed in muscle tissue and 9 other tissues.
DR   ExpressionAtlas; Q90VZ9; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..219
FT                   /note="Homeobox protein Hox-A7"
FT                   /id="PRO_0000200075"
FT   DNA_BIND        129..188
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          186..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           118..123
FT                   /note="Antp-type hexapeptide"
SQ   SEQUENCE   219 AA;  24953 MW;  4BAE9046D52C0705 CRC64;
     MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FASNSQRSGY GPGAGAFASS MPGLYNVNST
     IYQSPFSSGY SLGSDAYNLH CSSFDQNIPV LCNDLTKPSC EKAEESNLHN QAEANFRIYP
     WMRSSGPDRK RGRQTYTRYQ TLELEKEFHF NRYLTRRRRI EIAHALCLTE RQIKIWFQNR
     RMKWKKEHKE ESSSTPAPNE PTSAAASVEK VEEDEEEED