ID   HXA7_COTJA              Reviewed;         242 AA.
AC   P24061;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Homeobox protein Hox-A7;
DE   AltName: Full=Quox-1;
GN   Name=HOXA7; Synonyms=QUOX-1;
OS   Coturnix japonica (Japanese quail) (Coturnix coturnix japonica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Perdicinae; Coturnix.
OX   NCBI_TaxID=93934;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Spinal cord;
RX   PubMed=1672453; DOI=10.1073/pnas.88.6.2427;
RA   Xue Z.-G., Gehring W.J., le Douarin N.M.;
RT   "Quox-1, a quail homeobox gene expressed in the embryonic central nervous
RT   system, including the forebrain.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:2427-2431(1991).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Central nervous system including forebrain.
CC   -!- DEVELOPMENTAL STAGE: Embryo.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; M59714; AAA49501.1; -; Genomic_DNA.
DR   PIR; A39164; A39164.
DR   AlphaFoldDB; P24061; -.
DR   SMR; P24061; -.
DR   Proteomes; UP000694412; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Repeat; Transcription; Transcription regulation.
FT   CHAIN           1..242
FT                   /note="Homeobox protein Hox-A7"
FT                   /id="PRO_0000200076"
FT   REPEAT          183..186
FT                   /note="Motif KWKK"
FT   REPEAT          210..213
FT                   /note="Motif KWKK"
FT   DNA_BIND        129..188
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          187..227
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           118..123
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        208..222
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   242 AA;  28241 MW;  BCB4DBEB6B985F7F CRC64;
     MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FASNSQRSGY GPGAGAFASS MPGLYNVNST
     IYQSPFSSGY SLGSDAYNLH CSSFDQNIPV LCNDLTKPSC EKAEERQPAQ PGRGQFRIYP
     WMRSSGPDRK RGRQTYTRYQ TLELEKEFHF NRYLTRRRRI EYAHALCLTE RQIKIWFQNR
     RMKWKKEHKE ESSSTPAPNE SRQQQRLWRK WKKMKKRRIR ESHSRKQSLE ITYARDSCKS
     SL