HXA7_HUMAN
ID HXA7_HUMAN Reviewed; 230 AA.
AC P31268; A4D191; O43368; O43486; O95655; Q9NSC8; Q9UDM1;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 3.
DT 03-AUG-2022, entry version 190.
DE RecName: Full=Homeobox protein Hox-A7;
DE AltName: Full=Homeobox protein Hox 1.1;
DE AltName: Full=Homeobox protein Hox-1A;
GN Name=HOXA7; Synonyms=HOX1A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT THR-18.
RX PubMed=11435435; DOI=10.1074/jbc.m104598200;
RA La Celle P.T., Polakowska R.R.;
RT "Human homeobox HOXA7 regulates keratinocyte transglutaminase type 1 and
RT inhibits differentiation.";
RL J. Biol. Chem. 276:32844-32853(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT THR-18.
RX PubMed=9804983; DOI=10.1016/s0167-4781(98)00170-5;
RA McIlhatton M.A., Bremner P.S., McMullin M.F., Maxwell A.P., Winter P.C.,
RA Lappin T.R.;
RT "Sequence characterisation and expression of homeobox HOX A7 in the multi-
RT potential erythroleukaemic cell line TF-1.";
RL Biochim. Biophys. Acta 1442:329-333(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT THR-18.
RX PubMed=10911612; DOI=10.1385/mb:14:1:19;
RA Kim M.H., Jin H., Seol E.Y., Yoo M., Park H.W.;
RT "Sequence analysis and tissue specific expression of human HOXA7.";
RL Mol. Biotechnol. 14:19-24(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT THR-18.
RC TISSUE=Placenta;
RA Albrechtsen R., Wewer U.;
RL Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-91, AND VARIANT THR-18.
RA Cho M., Kim M.H., Hwang C.Y., Min W.;
RL Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 130-195.
RX PubMed=2576652; DOI=10.1139/g89-133;
RA Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R.,
RA Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.;
RT "Organization of human class I homeobox genes.";
RL Genome 31:745-756(1989).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- INTERACTION:
CC P31268; O00560: SDCBP; NbExp=3; IntAct=EBI-3910421, EBI-727004;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; AF026397; AAB94604.1; -; mRNA.
DR EMBL; AJ005814; CAA06713.1; -; mRNA.
DR EMBL; AF032095; AAD01939.2; -; Genomic_DNA.
DR EMBL; X84803; CAA59270.1; -; Genomic_DNA.
DR EMBL; X84804; CAA59270.1; JOINED; Genomic_DNA.
DR EMBL; CH236948; EAL24221.1; -; Genomic_DNA.
DR EMBL; AC004080; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471073; EAW93877.1; -; Genomic_DNA.
DR EMBL; U92543; AAD00727.1; -; Genomic_DNA.
DR CCDS; CCDS5408.1; -.
DR PIR; S15536; S15536.
DR RefSeq; NP_008827.2; NM_006896.3.
DR AlphaFoldDB; P31268; -.
DR SMR; P31268; -.
DR BioGRID; 109444; 90.
DR IntAct; P31268; 4.
DR STRING; 9606.ENSP00000242159; -.
DR iPTMnet; P31268; -.
DR PhosphoSitePlus; P31268; -.
DR BioMuta; HOXA7; -.
DR DMDM; 311033439; -.
DR jPOST; P31268; -.
DR MassIVE; P31268; -.
DR MaxQB; P31268; -.
DR PaxDb; P31268; -.
DR PeptideAtlas; P31268; -.
DR PRIDE; P31268; -.
DR ProteomicsDB; 54769; -.
DR Antibodypedia; 12389; 176 antibodies from 26 providers.
DR DNASU; 3204; -.
DR Ensembl; ENST00000242159.5; ENSP00000242159.3; ENSG00000122592.8.
DR GeneID; 3204; -.
DR KEGG; hsa:3204; -.
DR MANE-Select; ENST00000242159.5; ENSP00000242159.3; NM_006896.4; NP_008827.2.
DR UCSC; uc003sys.4; human.
DR CTD; 3204; -.
DR DisGeNET; 3204; -.
DR GeneCards; HOXA7; -.
DR HGNC; HGNC:5108; HOXA7.
DR HPA; ENSG00000122592; Low tissue specificity.
DR MIM; 142950; gene.
DR neXtProt; NX_P31268; -.
DR OpenTargets; ENSG00000122592; -.
DR PharmGKB; PA29385; -.
DR VEuPathDB; HostDB:ENSG00000122592; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000161013; -.
DR HOGENOM; CLU_061398_1_1_1; -.
DR InParanoid; P31268; -.
DR OMA; HKDEGPT; -.
DR OrthoDB; 1203627at2759; -.
DR PhylomeDB; P31268; -.
DR TreeFam; TF316310; -.
DR PathwayCommons; P31268; -.
DR SignaLink; P31268; -.
DR SIGNOR; P31268; -.
DR BioGRID-ORCS; 3204; 17 hits in 1094 CRISPR screens.
DR GeneWiki; HOXA7; -.
DR GenomeRNAi; 3204; -.
DR Pharos; P31268; Tbio.
DR PRO; PR:P31268; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; P31268; protein.
DR Bgee; ENSG00000122592; Expressed in oocyte and 134 other tissues.
DR ExpressionAtlas; P31268; baseline and differential.
DR Genevisible; P31268; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0031965; C:nuclear membrane; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IPI:UniProtKB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0001525; P:angiogenesis; IEP:UniProtKB.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Ensembl.
DR GO; GO:0001953; P:negative regulation of cell-matrix adhesion; IDA:UniProtKB.
DR GO; GO:0045617; P:negative regulation of keratinocyte differentiation; IDA:MGI.
DR GO; GO:0002686; P:negative regulation of leukocyte migration; IDA:UniProtKB.
DR GO; GO:0045656; P:negative regulation of monocyte differentiation; IDA:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0048863; P:stem cell differentiation; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017995; Homeobox_antennapedia.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00025; ANTENNAPEDIA.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..230
FT /note="Homeobox protein Hox-A7"
FT /id="PRO_0000200071"
FT DNA_BIND 130..189
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 187..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 119..124
FT /note="Antp-type hexapeptide"
FT COMPBIAS 215..230
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 18
FT /note="A -> T (in dbSNP:rs2301721)"
FT /evidence="ECO:0000269|PubMed:10911612,
FT ECO:0000269|PubMed:11435435, ECO:0000269|PubMed:9804983,
FT ECO:0000269|Ref.4, ECO:0000269|Ref.8"
FT /id="VAR_028001"
FT CONFLICT 75..76
FT /note="DA -> RR (in Ref. 8; AAD00727)"
FT /evidence="ECO:0000305"
FT CONFLICT 78
FT /note="Missing (in Ref. 4; CAA59270)"
FT /evidence="ECO:0000305"
FT CONFLICT 174
FT /note="I -> V (in Ref. 3; AAD01939)"
FT /evidence="ECO:0000305"
FT CONFLICT 194..195
FT /note="PT -> RL (in Ref. 4; CAA59270)"
FT /evidence="ECO:0000305"
FT CONFLICT 195
FT /note="T -> I (in Ref. 9; no nucleotide entry)"
FT /evidence="ECO:0000305"
FT CONFLICT 222
FT /note="D -> Y (in Ref. 4; CAA59270)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 230 AA; 25355 MW; 8F77A6B0AFB516D5 CRC64;
MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FAPNSQRSGY GAGAGAFAST VPGLYNVNSP
LYQSPFASGY GLGADAYGNL PCASYDQNIP GLCSDLAKGA CDKTDEGALH GAAEANFRIY
PWMRSSGPDR KRGRQTYTRY QTLELEKEFH FNRYLTRRRR IEIAHALCLT ERQIKIWFQN
RRMKWKKEHK DEGPTAAAAP EGAVPSAAAT AAADKADEED DDEEEEDEEE
