ID   HXA7_RAT                Reviewed;         105 AA.
AC   P09634;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 150.
DE   RecName: Full=Homeobox protein Hox-A7;
DE   AltName: Full=Homeobox protein Hox-1.1;
DE   AltName: Full=Homeobox protein R5;
DE   Flags: Fragment;
GN   Name=Hoxa7; Synonyms=Hoxa-7;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=2886401; DOI=10.1016/0378-1119(87)90343-x;
RA   Falzon M., Sanderson N., Chung S.Y.;
RT   "Cloning and expression of rat homeo-box-containing sequences.";
RL   Gene 54:23-32(1987).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; M16807; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; A27471; A27471.
DR   AlphaFoldDB; P09634; -.
DR   SMR; P09634; -.
DR   STRING; 10116.ENSRNOP00000065479; -.
DR   PhosphoSitePlus; P09634; -.
DR   PaxDb; P09634; -.
DR   PRIDE; P09634; -.
DR   UCSC; RGD:1587253; rat.
DR   RGD; 1587253; Hoxa7.
DR   eggNOG; KOG0489; Eukaryota.
DR   InParanoid; P09634; -.
DR   PhylomeDB; P09634; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0003677; F:DNA binding; ISO:RGD.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:RGD.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0140297; F:DNA-binding transcription factor binding; ISO:RGD.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISO:RGD.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR   GO; GO:0001525; P:angiogenesis; ISO:RGD.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; ISO:RGD.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; ISO:RGD.
DR   GO; GO:0001953; P:negative regulation of cell-matrix adhesion; ISO:RGD.
DR   GO; GO:0045617; P:negative regulation of keratinocyte differentiation; ISO:RGD.
DR   GO; GO:0002686; P:negative regulation of leukocyte migration; ISO:RGD.
DR   GO; GO:0045656; P:negative regulation of monocyte differentiation; ISO:RGD.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0048863; P:stem cell differentiation; ISO:RGD.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           <1..105
FT                   /note="Homeobox protein Hox-A7"
FT                   /id="PRO_0000200073"
FT   DNA_BIND        5..64
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          62..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        88..105
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   105 AA;  12552 MW;  106C1DF938F2864B CRC64;
     LGPDGKRGRQ TYTRYQTLEL EKEFHFNRYL TRRRAVEIAH ALCLTERQIK IWFQNRRMKW
     KKEHKDESQA PTAVPEDAVP SVSTAADKAD EEEEEEEEEE EEEEE