ID   HXA7_XENLA              Reviewed;         209 AA.
AC   P09071;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Homeobox protein Hox-A7;
DE   AltName: Full=Xhox-36;
DE   AltName: Full=XlHbox-3;
GN   Name=hoxa7;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=2452727;
RA   Condie B.G., Harland R.M.;
RT   "Posterior expression of a homeobox gene in early Xenopus embryos.";
RL   Development 101:93-105(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 119-209.
RX   PubMed=2894634; DOI=10.1093/nar/16.4.1453;
RA   Fritz A., De Robertis E.M.;
RT   "Xenopus homeobox-containing cDNAs expressed in early development.";
RL   Nucleic Acids Res. 16:1453-1469(1988).
RN   [3]
RP   INDUCTION.
RX   PubMed=10068640; DOI=10.1242/dev.126.7.1467;
RA   Sun B.I., Bush S.M., Collins-Racie L.A., LaVallie E.R.,
RA   DiBlasio-Smith E.A., Wolfman N.M., McCoy J.M., Sive H.L.;
RT   "derriere: a TGF-beta family member required for posterior development in
RT   Xenopus.";
RL   Development 126:1467-1482(1999).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC       {ECO:0000269|PubMed:2452727}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: Expressed exclusively in the posterior mesoderm
CC       and ectoderm of early Xenopus embryos.
CC   -!- INDUCTION: By derriere. {ECO:0000269|PubMed:10068640}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA30124.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; M24752; AAA49753.1; -; mRNA.
DR   EMBL; X07103; CAA30124.1; ALT_INIT; mRNA.
DR   PIR; A43553; A43553.
DR   RefSeq; NP_001082538.1; NM_001089069.1.
DR   AlphaFoldDB; P09071; -.
DR   SMR; P09071; -.
DR   GeneID; 398549; -.
DR   KEGG; xla:398549; -.
DR   CTD; 398549; -.
DR   Xenbase; XB-GENE-865003; hoxa7.L.
DR   OMA; HKDEGPT; -.
DR   OrthoDB; 1203627at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 398549; Expressed in neurula embryo and 9 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..209
FT                   /note="Homeobox protein Hox-A7"
FT                   /id="PRO_0000200079"
FT   DNA_BIND        122..181
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          25..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          179..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           111..116
FT                   /note="Antp-type hexapeptide"
SQ   SEQUENCE   209 AA;  23985 MW;  4EAC0A052F05D70D CRC64;
     MTSSYYVSAL FSKFTAGASL FPNPEPTSCS SLPNNSQRGA YGSGTGPFPS SVPSLYSSPL
     YQNPFPGYSL ASDSYNLHCS SFDQNIPLLC NELPKADEAA LHHQPDSHFR IYPWMRSSGP
     DRKRGRQTYT RYQTLELEKE FHFNRYLTRR RRIEIAHALC LTERQIKIWF QNRRMKWKKE
     HKEESDQTPD AGEESTAPTT TADDDKDKE