ID   HXA9_CAVPO              Reviewed;         162 AA.
AC   P51783;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Homeobox protein Hox-A9;
DE   AltName: Full=Homeobox protein Hox-1.7;
DE   Flags: Fragment;
GN   Name=HOXA9; Synonyms=HOX-1.7;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Kidney;
RX   PubMed=1983703; DOI=10.3109/10425179009016039;
RA   Rubin M.R., Nguyen-Huu M.C.;
RT   "Alternatively spliced Hox-1.7 transcripts encode different protein
RT   products.";
RL   DNA Seq. 1:115-124(1990).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR   EMBL; X13536; CAA31887.1; -; mRNA.
DR   PIR; A48428; A48428.
DR   AlphaFoldDB; P51783; -.
DR   SMR; P51783; -.
DR   STRING; 10141.ENSCPOP00000010215; -.
DR   PRIDE; P51783; -.
DR   eggNOG; KOG0487; Eukaryota.
DR   InParanoid; P51783; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0045638; P:negative regulation of myeloid cell differentiation; ISS:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           <1..162
FT                   /note="Homeobox protein Hox-A9"
FT                   /id="PRO_0000200080"
FT   DNA_BIND        96..155
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          56..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        63..79
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   162 AA;  18661 MW;  B84FA507EC67CF91 CRC64;
     NSGTVLLLVS EGGSSRSRSS WCCNLKQLAF AGLAGDPAWR SQLPLGSDSE MCQVDREKQP
     NEGAFSENNA ENDSSGDKPP IDPNNPAANW LHARSTRKKR CPYTKHQTLE LEKEFLFNMY
     LTRDRRYEVA RLLNLTERQV KIWFQNRRMK MKKINKDRAK DE