ID   HXAAB_TAKRU             Reviewed;         331 AA.
AC   Q1KKZ4;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Homeobox protein Hox-A10b;
GN   Name=hoxa10b;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16636282; DOI=10.1073/pnas.0601492103;
RA   Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.;
RT   "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved
RT   regulatory elements within and outside Hox gene clusters.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR   EMBL; DQ481664; ABF22400.1; -; Genomic_DNA.
DR   RefSeq; XP_003966152.1; XM_003966103.2.
DR   AlphaFoldDB; Q1KKZ4; -.
DR   SMR; Q1KKZ4; -.
DR   STRING; 31033.ENSTRUP00000039167; -.
DR   GeneID; 101079592; -.
DR   KEGG; tru:101079592; -.
DR   CTD; 30391; -.
DR   eggNOG; KOG0487; Eukaryota.
DR   InParanoid; Q1KKZ4; -.
DR   OrthoDB; 976319at2759; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR046333; HXA10/ABDB-like.
DR   PANTHER; PTHR45874; PTHR45874; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..331
FT                   /note="Homeobox protein Hox-A10b"
FT                   /id="PRO_0000265970"
FT   DNA_BIND        257..316
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          158..251
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        166..182
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        183..197
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   331 AA;  37157 MW;  DDA1BA8C132C0BF9 CRC64;
     MTCPNNQAGN SFFVDSLINV RPDSGSYYQS NGVYLPPGSE FSYGLSGGSC FPGIGKRNEP
     SAQSVISSPA PYVQGMETWL EASRPCRVDQ PRGQHMAQCS FSPNIKEEST YCLYESDKCP
     KGATVDDISY SASSCPVTST FPVPGYFRLS QTYASSRHYH DAHPNTDHFT LQQSARPDSR
     SSHRQAASAE PEQRANREES PVCAPCVPVR EEDSRLSSEG SSSPEPAETP SLECPEKSGK
     GDGKNETAAN WLTAKSGRKK RCPYTKHQTL ELEKEFLFNM YLTRERRLEI SRSVHLTDRQ
     VKIWFQNRRM KLKKMTRENR IRELSNSFSF S