ID   HXABB_DANRE             Reviewed;         283 AA.
AC   Q9DDU1; P79723; Q4PRA4;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Homeobox protein Hox-A11b;
DE            Short=Hox-A11;
GN   Name=hoxa11b; Synonyms=hoxa11;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11083943; DOI=10.1006/mpev.2000.0837;
RA   Chiu C.-H., Nonaka D., Xue L., Amemiya C.T., Wagner G.P.;
RT   "Evolution of Hoxa-11 in lineages phylogenetically positioned along the
RT   fin-limb transition.";
RL   Mol. Phylogenet. Evol. 17:305-316(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 125-215.
RC   STRAIN=Tuebingen;
RX   PubMed=16174031; DOI=10.1111/j.1525-142x.2005.05042.x;
RA   Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T.,
RA   de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J.,
RA   Richardson M.K.;
RT   "Genomic annotation and transcriptome analysis of the zebrafish (Danio
RT   rerio) hox complex with description of a novel member, hoxb13a.";
RL   Evol. Dev. 7:362-375(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 211-270, AND DEVELOPMENTAL STAGE.
RX   PubMed=8951794; DOI=10.1016/0925-4773(96)00587-4;
RA   Sordino P., Duboule D., Kondo T.;
RT   "Zebrafish Hoxa and Evx-2 genes: cloning, developmental expression and
RT   implications for the functional evolution of posterior Hox genes.";
RL   Mech. Dev. 59:165-175(1996).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: First detected at 11.5 hours post-fertilization
CC       (hpf) in dorsal presomitic mesoderm and in the neural keel, extending
CC       to the ventral somitic mesoderm during tail budding. At 16-19 hpf, the
CC       rostral expression boundary is at somite 10. By the end of
CC       somitogenesis, expression decreases in the lateral and ventral mesoderm
CC       and becomes restricted to the neural rod. Also expressed in the
CC       developing pectoral fins from 34 hpf, with progressive localization to
CC       the periphery. {ECO:0000269|PubMed:8951794}.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR   EMBL; AF287137; AAG39068.1; -; Genomic_DNA.
DR   EMBL; DQ060539; AAY67917.1; -; mRNA.
DR   EMBL; Y07698; CAA68960.1; -; Genomic_DNA.
DR   RefSeq; NP_571222.1; NM_131147.1.
DR   AlphaFoldDB; Q9DDU1; -.
DR   SMR; Q9DDU1; -.
DR   STRING; 7955.ENSDARP00000005174; -.
DR   PaxDb; Q9DDU1; -.
DR   GeneID; 30382; -.
DR   KEGG; dre:30382; -.
DR   CTD; 30382; -.
DR   ZFIN; ZDB-GENE-990415-4; hoxa11b.
DR   eggNOG; KOG0487; Eukaryota.
DR   InParanoid; Q9DDU1; -.
DR   OrthoDB; 976319at2759; -.
DR   PhylomeDB; Q9DDU1; -.
DR   PRO; PR:Q9DDU1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR021918; DUF3528.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF12045; DUF3528; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..283
FT                   /note="Homeobox protein Hox-A11b"
FT                   /id="PRO_0000200099"
FT   DNA_BIND        211..270
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          150..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        189..212
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        269
FT                   /note="L -> M (in Ref. 3)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   283 AA;  32315 MW;  0D816C6F49F9BC6E CRC64;
     MMDFDERVPV GSNMYLPGCT YYVSGTDFSS LPPFLPQTPS SCPMTYSYST SSLPQVQSVR
     EVSFRDYAID TSSKWHSRGN LPHCYATEDM VHRECLSNPG TLGDMLSKNN SVLYHSNSSH
     TSNVYGSVGR NGVLPQAFDQ FFETAYGNVE NQPTEHPVDR ATSKAPPPAE SGSDSCRGTD
     ETERCEETSS PEPSSGNNED KFSGSSNGQK TRKKRCPYTK YQIRELEREF FFSVYINKEK
     RLQLSRMLNL TDRQVKIWFQ NRRMKEKKLN RDRLQYYTTN PLL