ID   HXABB_DEVAE             Reviewed;         283 AA.
AC   Q9DDU2;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Homeobox protein Hox-A11b;
GN   Name=hoxa11b;
OS   Devario aequipinnatus (Giant danio) (Danio aequipinnatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Devario.
OX   NCBI_TaxID=46778;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11083943; DOI=10.1006/mpev.2000.0837;
RA   Chiu C.-H., Nonaka D., Xue L., Amemiya C.T., Wagner G.P.;
RT   "Evolution of Hoxa-11 in lineages phylogenetically positioned along the
RT   fin-limb transition.";
RL   Mol. Phylogenet. Evol. 17:305-316(2000).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR   EMBL; AF287136; AAG39067.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9DDU2; -.
DR   SMR; Q9DDU2; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR021918; DUF3528.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF12045; DUF3528; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..283
FT                   /note="Homeobox protein Hox-A11b"
FT                   /id="PRO_0000200100"
FT   DNA_BIND        211..270
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          147..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        189..212
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   283 AA;  32401 MW;  1E68B49F26EAD723 CRC64;
     MMDFDERVPV GSNMYLPGCT YYVSGTDFSS LPPFLPQTPS SCPMTYSYST SSLPQVQSVR
     EVSFRDYAID TSSKWHSRGN LPHCYATEDM VHRDCLSNPG TLGDMLSKNN SVLYHSNTNH
     ASNMYGNVGR NGVLPQAFDQ FFETTYGNVE NQPTDHPVDR TASKAPPPAE SGSDSCRGTD
     ETERCEETSS PEPSSGNNEE KFSGSSNGQK TRKKRCPYTK YQIRELEREF FFSVYINKEK
     RLQLSRMLNL TDRQVKIWFQ NRRMKEKKLN RDRLQYYTTN PLL