ID   HXADA_DANRE             Reviewed;         310 AA.
AC   Q6W990; Q1L974; Q9YGT9;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 2.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Homeobox protein Hox-A13a;
GN   Name=hoxa13a;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=14707165; DOI=10.1101/gr.1717804;
RA   Amores A., Suzuki T., Yan Y.-L., Pomeroy J., Singer A., Amemiya C.,
RA   Postlethwait J.H.;
RT   "Developmental roles of pufferfish Hox clusters and genome evolution in
RT   ray-fin fish.";
RL   Genome Res. 14:1-10(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 244-310.
RX   PubMed=9831563; DOI=10.1126/science.282.5394.1711;
RA   Amores A., Force A., Yan Y.-L., Joly L., Amemiya C., Fritz A., Ho R.K.,
RA   Langeland J., Prince V.E., Wang Y.-L., Westerfield M., Ekker M.,
RA   Postlethwait J.H.;
RT   "Zebrafish hox clusters and vertebrate genome evolution.";
RL   Science 282:1711-1714(1998).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY303229; AAQ72839.1; -; Genomic_DNA.
DR   EMBL; CR382300; CAK10846.1; -; Genomic_DNA.
DR   EMBL; AF071241; AAD15935.1; -; Genomic_DNA.
DR   RefSeq; NP_001078963.1; NM_001085494.1.
DR   AlphaFoldDB; Q6W990; -.
DR   SMR; Q6W990; -.
DR   STRING; 7955.ENSDARP00000003928; -.
DR   PaxDb; Q6W990; -.
DR   Ensembl; ENSDART00000171610; ENSDARP00000135830; ENSDARG00000100312.
DR   GeneID; 570239; -.
DR   KEGG; dre:570239; -.
DR   CTD; 570239; -.
DR   ZFIN; ZDB-GENE-990415-5; hoxa13a.
DR   eggNOG; KOG0487; Eukaryota.
DR   GeneTree; ENSGT00940000164071; -.
DR   HOGENOM; CLU_059940_1_0_1; -.
DR   InParanoid; Q6W990; -.
DR   OMA; CHECQEQ; -.
DR   OrthoDB; 1190384at2759; -.
DR   PhylomeDB; Q6W990; -.
DR   TreeFam; TF330813; -.
DR   PRO; PR:Q6W990; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 19.
DR   Bgee; ENSDARG00000100312; Expressed in mesenchyme pectoral fin and 12 other tissues.
DR   ExpressionAtlas; Q6W990; baseline.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:ZFIN.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0033333; P:fin development; IMP:ZFIN.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR022067; HoxA13_N.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF12284; HoxA13_N; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..310
FT                   /note="Homeobox protein Hox-A13a"
FT                   /id="PRO_0000200104"
FT   DNA_BIND        244..303
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   CONFLICT        183
FT                   /note="S -> W (in Ref. 1; AAQ72839)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   310 AA;  33745 MW;  71F19FF3C707B317 CRC64;
     MTTSLLLRPR WIDPVMFLYD NGGGLDDTSK NMEGFTGGNF SPSPCRNLMS HPASLAPSAT
     YPSSEVAAAA AGDSGKQCSP CSAVQGSASA SISYGYFGGG GYYPCRMSHH HGSGGGVKTC
     AQSPASGSPY GEKYMDTSAS TGEDYTSSRA KEFALYSSYA SSPYQPVPSY LDVPVVQAIS
     GPSEPRHESL LPMESYQPWA ITTSGWNGQV YCTKEQQQTG NVWKSSIPES VSHGGADGSS
     FRRGRKKRVP YTKVQLKELE REYATNKFIT KDKRRRISAQ TNLSERQVTI WFQNRRVKEK
     KVVNKLKSSS