ID   HXADB_DANRE             Reviewed;         289 AA.
AC   P79724; Q5CZP9; Q9PWL4;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 3.
DT   03-AUG-2022, entry version 147.
DE   RecName: Full=Homeobox protein Hox-A13b;
DE            Short=Hox-A13;
GN   Name=hoxa13b; Synonyms=hoxa-13, hoxa13; ORFNames=zgc:110514;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9831563; DOI=10.1126/science.282.5394.1711;
RA   Amores A., Force A., Yan Y.-L., Joly L., Amemiya C., Fritz A., Ho R.K.,
RA   Langeland J., Prince V.E., Wang Y.-L., Westerfield M., Ekker M.,
RA   Postlethwait J.H.;
RT   "Zebrafish hox clusters and vertebrate genome evolution.";
RL   Science 282:1711-1714(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 219-278, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Embryo;
RX   PubMed=8951794; DOI=10.1016/0925-4773(96)00587-4;
RA   Sordino P., Duboule D., Kondo T.;
RT   "Zebrafish Hoxa and Evx-2 genes: cloning, developmental expression and
RT   implications for the functional evolution of posterior Hox genes.";
RL   Mech. Dev. 59:165-175(1996).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P79724-2; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P79724-1; Sequence=VSP_019622;
CC   -!- DEVELOPMENTAL STAGE: First detected at 12.5 hours post-fertilization
CC       (hpf) in dorsal presomitic mesoderm and in the neural keel, extending
CC       to the ventral somitic mesoderm during tail budding. At 16-19 hpf,
CC       restricted to the posterior end of the somitic mesoderm. Also expressed
CC       in the developing pectoral fins from 34 hpf, with progressive
CC       localization to the periphery. {ECO:0000269|PubMed:8951794}.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH90761.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF071242; AAD15936.1; -; Genomic_DNA.
DR   EMBL; BC090761; AAH90761.1; ALT_INIT; mRNA.
DR   EMBL; Y07699; CAA68961.1; -; mRNA.
DR   RefSeq; NP_571269.2; NM_131194.2. [P79724-2]
DR   AlphaFoldDB; P79724; -.
DR   SMR; P79724; -.
DR   STRING; 7955.ENSDARP00000052661; -.
DR   PaxDb; P79724; -.
DR   Ensembl; ENSDART00000052662; ENSDARP00000052661; ENSDARG00000036254. [P79724-2]
DR   GeneID; 30438; -.
DR   KEGG; dre:30438; -.
DR   CTD; 30438; -.
DR   ZFIN; ZDB-GENE-980526-365; hoxa13b.
DR   eggNOG; KOG0487; Eukaryota.
DR   GeneTree; ENSGT00940000164071; -.
DR   HOGENOM; CLU_059940_1_0_1; -.
DR   InParanoid; P79724; -.
DR   OMA; WSSPVYC; -.
DR   OrthoDB; 1190384at2759; -.
DR   PhylomeDB; P79724; -.
DR   TreeFam; TF330813; -.
DR   PRO; PR:P79724; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 16.
DR   Bgee; ENSDARG00000036254; Expressed in pectoral fin fold and 13 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:ZFIN.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0033333; P:fin development; IMP:ZFIN.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR022067; HoxA13_N.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF12284; HoxA13_N; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Developmental protein; DNA-binding; Homeobox;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..289
FT                   /note="Homeobox protein Hox-A13b"
FT                   /id="PRO_0000200105"
FT   DNA_BIND        223..282
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   VAR_SEQ         210..213
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_019622"
FT   CONFLICT        144..146
FT                   /note="GPY -> ALT (in Ref. 1; AAD15936)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   289 AA;  32396 MW;  725A0443114D1D1F CRC64;
     MTASLLLHSR WIDPVMFLYD NGLDDMSKNM EGFVGGNFAA NQCRNLIAHP STLAPSTTYT
     SSEVPVSGMG EPVKQCSPCS AVQNTPSASL PYGYFGGSYY PCRMPKSCTQ PTTYGEKYMD
     TSVSGEEFPS RAKEFAFYQG YSSGPYQPVP SYLDVPVVPA LSAPSEPRHE SLLPVETYQP
     WAITNGWSSP VYCPKDQTQS STLWKSSIQD TVSGTDGASV RRGRKKRVPY TKVQLKELER
     EYATNKFITK DKRRRISAHT NLTERQVTIW FQNRRVKEKK VVNKYKGIS