HXB13_MOUSE
ID HXB13_MOUSE Reviewed; 286 AA.
AC P70321; Q80Y12;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Homeobox protein Hox-B13;
GN Name=Hoxb13;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8756292; DOI=10.1242/dev.122.8.2475;
RA Zeltser L.M., Desplan C., Heintz N.;
RT "Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains
RT colinearity.";
RL Development 122:2475-2484(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. Binds
CC preferentially to methylated DNA (By similarity).
CC {ECO:0000250|UniProtKB:Q92826}.
CC -!- SUBUNIT: Heterodimer with MEIS1 and MEIS2.
CC {ECO:0000250|UniProtKB:Q92826}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Exhibits both spatial and temporal colinearity
CC within the main body axis. At 12.5 dpc, is detected in hindgut,
CC urogenital tract, spinal cord and tailbud. Not detected in secondary
CC axes such as the limb and the genital tubercule.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR EMBL; U57051; AAC52769.1; -; mRNA.
DR EMBL; BC013639; AAH13639.1; -; mRNA.
DR EMBL; BC051087; AAH51087.2; -; mRNA.
DR EMBL; BC058813; AAH58813.1; -; mRNA.
DR CCDS; CCDS25291.1; -.
DR RefSeq; NP_032293.1; NM_008267.3.
DR AlphaFoldDB; P70321; -.
DR SMR; P70321; -.
DR BioGRID; 200376; 4.
DR IntAct; P70321; 5.
DR STRING; 10090.ENSMUSP00000056315; -.
DR PhosphoSitePlus; P70321; -.
DR PaxDb; P70321; -.
DR PRIDE; P70321; -.
DR ProteomicsDB; 273229; -.
DR Antibodypedia; 3837; 271 antibodies from 29 providers.
DR DNASU; 15408; -.
DR Ensembl; ENSMUST00000062709; ENSMUSP00000056315; ENSMUSG00000049604.
DR GeneID; 15408; -.
DR KEGG; mmu:15408; -.
DR UCSC; uc007lbk.1; mouse.
DR CTD; 10481; -.
DR MGI; MGI:107730; Hoxb13.
DR VEuPathDB; HostDB:ENSMUSG00000049604; -.
DR eggNOG; KOG0487; Eukaryota.
DR GeneTree; ENSGT00940000159029; -.
DR HOGENOM; CLU_059940_1_0_1; -.
DR InParanoid; P70321; -.
DR OMA; HPPDGCA; -.
DR OrthoDB; 1190384at2759; -.
DR PhylomeDB; P70321; -.
DR TreeFam; TF330813; -.
DR BioGRID-ORCS; 15408; 1 hit in 75 CRISPR screens.
DR PRO; PR:P70321; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; P70321; protein.
DR Bgee; ENSMUSG00000049604; Expressed in prostate gland ventral lobe and 36 other tissues.
DR Genevisible; P70321; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005667; C:transcription regulator complex; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0008327; F:methyl-CpG binding; ISS:UniProtKB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0060743; P:epithelial cell maturation involved in prostate gland development; IMP:MGI.
DR GO; GO:0002009; P:morphogenesis of an epithelium; IMP:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0060527; P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; IGI:MGI.
DR GO; GO:0040008; P:regulation of growth; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0033574; P:response to testosterone; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR022067; HoxA13_N.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF12284; HoxA13_N; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..286
FT /note="Homeobox protein Hox-B13"
FT /id="PRO_0000200161"
FT DNA_BIND 218..277
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 219..248
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250|UniProtKB:Q92826"
FT REGION 260..275
FT /note="Interaction with 5-mCpG DNA"
FT /evidence="ECO:0000250|UniProtKB:Q92826"
FT REGION 272..275
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250|UniProtKB:Q92826"
SQ SEQUENCE 286 AA; 30963 MW; 1A6BFB4C4720E25F CRC64;
MEPGNYATLD GAKDIEGLLG AGGGRNLVSH SSPLASHPAA PTLMPTVNYA PLDLPGSAEP
PKQCHPCPGV PQGASPAPVP YGYFGGGYYS CRVSRSSLKP CAQTAALATY PSETPAPGEE
YPSRPTEFAF YPGYPGPYQP MASYLDVSVV QTLGAPGEPR HDSLLPVDSY QPWALAGGWN
SQMCCQGEQN PPGPFWKAAF AEPSVQHPPP DGCAFRRGRK KRIPYSKGQL RELEREYAAN
KFITKDKRRK ISAATSLSER QITIWFQNRR VKEKKVLAKV KTSTTP
