ID   HXB1_AMBME              Reviewed;         184 AA.
AC   P31357;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Homeobox protein Hox-B1;
DE   AltName: Full=AHox1;
DE   Flags: Fragment;
OS   Ambystoma mexicanum (Axolotl).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Caudata; Salamandroidea; Ambystomatidae; Ambystoma.
OX   NCBI_TaxID=8296;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1695851; DOI=10.1139/o90-088;
RA   Whiteley M.H., Armstrong J.B.;
RT   "Isolation and characterization of a developmentally regulated homeobox
RT   sequence in the Mexican axolotl Ambystoma mexicanum.";
RL   Biochem. Cell Biol. 68:622-629(1990).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. Acts on the
CC       anterior body structures (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. Labial subfamily.
CC       {ECO:0000305}.
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DR   EMBL; X15575; CAA33599.1; -; Genomic_DNA.
DR   PIR; A37041; A37041.
DR   AlphaFoldDB; P31357; -.
DR   SMR; P31357; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR046327; HXA1/B1/D1.
DR   PANTHER; PTHR45946; PTHR45946; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           <1..184
FT                   /note="Homeobox protein Hox-B1"
FT                   /id="PRO_0000200113"
FT   DNA_BIND        87..146
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          140..184
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        163..184
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   184 AA;  20012 MW;  9F43DF041E1A7DFD CRC64;
     GTPTTACSLP GGGGGWLWGG TCVQAMGRGG HRPSDGHLSP SPCCAFFSRC LCCFFGLYAL
     STSLALISSL FSLLTAKLSE YGLGSQQNSI RTNFTTKQLS ELEKEFHFNK YLTRARRVEI
     AATLELNETQ VKIWFQNRRM KQKKREKEGL APSNGPQGRA REASEASDQS SSPSPYASPD
     SFSS