HXB1_CHICK
ID HXB1_CHICK Reviewed; 309 AA.
AC P31259;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Homeobox protein Hox-B1;
DE AltName: Full=Ghox-lab;
GN Name=HOXB1; Synonyms=GHOX-LAB;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1693558; DOI=10.1242/dev.108.supplement.47;
RA Sundin O.H., Busse H.G., Rogers M.B., Gudas L.J., Eichele G.;
RT "Region-specific expression in early chick and mouse embryos of Ghox-lab
RT and Hox 1.6, vertebrate homeobox-containing genes related to Drosophila
RT labial.";
RL Development 108:47-58(1990).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. Acts on the
CC anterior body structures.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. Labial subfamily.
CC {ECO:0000305}.
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DR EMBL; X68352; CAA48418.1; -; Genomic_DNA.
DR EMBL; X68353; CAA48418.1; JOINED; Genomic_DNA.
DR PIR; A60096; A60096.
DR AlphaFoldDB; P31259; -.
DR SMR; P31259; -.
DR STRING; 9031.ENSGALP00000021895; -.
DR PaxDb; P31259; -.
DR VEuPathDB; HostDB:geneid_395900; -.
DR eggNOG; KOG0489; Eukaryota.
DR InParanoid; P31259; -.
DR PhylomeDB; P31259; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR046327; HXA1/B1/D1.
DR PANTHER; PTHR45946; PTHR45946; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..309
FT /note="Homeobox protein Hox-B1"
FT /id="PRO_0000200109"
FT DNA_BIND 213..272
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 28..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 188..193
FT /note="Antp-type hexapeptide"
FT COMPBIAS 28..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 309 AA; 33833 MW; 7F229226B51D607D CRC64;
MDNTRMNSFL EYAICNRGTG AYHHLEQSSP SFPSCSGSPS SDTFHGEGAY GAGGSPVAAA
HLPPQSPGFF PAPPGAPSLR GRCPERRVPN PKLQPRLRHH QLYLGQQDAD AVYFQAAGYS
SSTGPHLGSL AEGYCGAVGQ YQQQQHLYGQ EQPSYLPGVY GNLSPSLNED KDPACPSEPC
PNASRARTFD WMKVKRNPPK TAKVSEYGLL GQPNTIRTNF TTKQLTELEK EFHFNKYLTR
ARRVEIAATL ELNETQVKIW FQNRRMKQKK REKEGLAPPA ASRSAKEASE ASDQSNCTSP
EASPSSVSS
