ID   HXB2A_TAKRU             Reviewed;         415 AA.
AC   Q6IEI0;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Homeobox protein Hox-B2a;
GN   Name=hoxb2a;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Hadrys T., Prince V.E., Hunter M., Baker R., Rinkwitz S.;
RT   "Comparative genomic analysis of vertebrate Hox3 and Hox4 genes.";
RL   J. Exp. Zool. B Mol. Dev. Evol. 302:147-164(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16636282; DOI=10.1073/pnas.0601492103;
RA   Lee A.P., Koh E.G.L., Tay A., Brenner S., Venkatesh B.;
RT   "Highly conserved syntenic blocks at the vertebrate Hox loci and conserved
RT   regulatory elements within and outside Hox gene clusters.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6994-6999(2006).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. Proboscipedia
CC       subfamily. {ECO:0000305}.
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DR   EMBL; BK005104; DAA05216.1; -; Genomic_DNA.
DR   EMBL; DQ481665; ABF22418.1; -; Genomic_DNA.
DR   RefSeq; XP_003964308.1; XM_003964259.2.
DR   AlphaFoldDB; Q6IEI0; -.
DR   SMR; Q6IEI0; -.
DR   STRING; 31033.ENSTRUP00000025073; -.
DR   Ensembl; ENSTRUT00000025179; ENSTRUP00000025076; ENSTRUG00000009966.
DR   GeneID; 101073209; -.
DR   KEGG; tru:101073209; -.
DR   CTD; 30338; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000155029; -.
DR   InParanoid; Q6IEI0; -.
DR   OrthoDB; 835724at2759; -.
DR   Proteomes; UP000005226; Chromosome 5.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..415
FT                   /note="Homeobox protein Hox-B2a"
FT                   /id="PRO_0000265977"
FT   DNA_BIND        173..232
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          43..171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          225..360
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           109..114
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        54..89
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        142..166
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        258..300
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        314..360
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   415 AA;  44044 MW;  1F0246C6ECD070EB CRC64;
     MNFEFEREIG FINSQPSLAE CLTSFPAVLE SFQTSSIKES TVIPPPFEHT IPSLSPCAAS
     QPRPTARNQQ NRRNSNTNGI QTHQRAAQQP CPPGQAPATA TAAGPMAPEF PWMKEKKSSK
     KSSKPGSSSG GGAPILPPSS ASPSPTASGY ASASIESPTD QSQAGLDAGG AGSRRLRTAY
     TNTQLLELEK EFHFNKYLCR PRRVEIAALL DLTERQVKVW FQNRRMKHKR QTHHRDGSGG
     GNDSNEPGGF EPLEGADASS PYSSQPLEAS GTGESESEQG SSNPSSAAYA SDSGDNAQST
     AEEGGLLGCP DRQSLSAVSG SSATHLHPLT ATNSSDNQAP LQLNRTGPEP SFSEQRDSSI
     PSATAALPDL TLFATDACLS PSLQSSLDSP VDFSEEDFDL FTSTLCTIDL QHLNF