HXB2_MOUSE
ID HXB2_MOUSE Reviewed; 354 AA.
AC P0C1T1; A2A739; B9EHW9;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Homeobox protein Hox-B2;
DE AltName: Full=Homeobox protein Hox-2.8;
GN Name=Hoxb2; Synonyms=Hox-2.8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP DEVELOPMENTAL STAGE.
RX PubMed=8093858; DOI=10.1016/0092-8674(93)90659-e;
RA Sham M.H., Vesque C., Nonchev S., Marshall H., Frain M., Gupta R.D.,
RA Whiting J., Wilkinson D., Charnay P., Krumlauf R.;
RT "The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain
RT segmentation.";
RL Cell 72:183-196(1993).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. {ECO:0000250}.
CC -!- SUBUNIT: Part of the nuclear protein complex gamma-globin promoter and
CC enhancer binding factor (gamma-PE) composed at least by SATB1 and
CC HOXB2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- DEVELOPMENTAL STAGE: At 8 dpc, expressed in the developing hindbrain in
CC regions that give rise to rhombomeric segmentations r3, r4 and r5.
CC {ECO:0000269|PubMed:8093858}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. Proboscipedia
CC subfamily. {ECO:0000305}.
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DR EMBL; AL606824; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC138494; AAI38495.1; -; mRNA.
DR EMBL; BC138495; AAI38496.1; -; mRNA.
DR CCDS; CCDS36290.1; -.
DR RefSeq; NP_598793.2; NM_134032.2.
DR AlphaFoldDB; P0C1T1; -.
DR SMR; P0C1T1; -.
DR BioGRID; 222192; 1.
DR STRING; 10090.ENSMUSP00000098092; -.
DR PhosphoSitePlus; P0C1T1; -.
DR PaxDb; P0C1T1; -.
DR PRIDE; P0C1T1; -.
DR Antibodypedia; 30263; 171 antibodies from 27 providers.
DR DNASU; 103889; -.
DR Ensembl; ENSMUST00000100523; ENSMUSP00000098092; ENSMUSG00000075588.
DR GeneID; 103889; -.
DR KEGG; mmu:103889; -.
DR UCSC; uc007lby.1; mouse.
DR CTD; 3212; -.
DR MGI; MGI:96183; Hoxb2.
DR VEuPathDB; HostDB:ENSMUSG00000075588; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000155029; -.
DR HOGENOM; CLU_048378_0_0_1; -.
DR InParanoid; P0C1T1; -.
DR OMA; EDICDPA; -.
DR OrthoDB; 835724at2759; -.
DR PhylomeDB; P0C1T1; -.
DR TreeFam; TF317730; -.
DR BioGRID-ORCS; 103889; 7 hits in 72 CRISPR screens.
DR ChiTaRS; Hoxb2; mouse.
DR PRO; PR:P0C1T1; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; P0C1T1; protein.
DR Bgee; ENSMUSG00000075588; Expressed in rhombomere 3 and 90 other tissues.
DR Genevisible; P0C1T1; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IGI:MGI.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IGI:MGI.
DR GO; GO:0021612; P:facial nerve structural organization; IMP:MGI.
DR GO; GO:0002011; P:morphogenesis of an epithelial sheet; IGI:MGI.
DR GO; GO:0048857; P:neural nucleus development; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0021569; P:rhombomere 3 development; IGI:MGI.
DR GO; GO:0021570; P:rhombomere 4 development; IGI:MGI.
DR GO; GO:0048705; P:skeletal system morphogenesis; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..354
FT /note="Homeobox protein Hox-B2"
FT /id="PRO_0000248841"
FT DNA_BIND 141..200
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 39..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 92..97
FT /note="Antp-type hexapeptide"
FT COMPBIAS 54..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..92
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 272
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P14652"
SQ SEQUENCE 354 AA; 38096 MW; BA5EB460770DA045 CRC64;
MNFEFEREIG FINSQPSLAE CLTSFPAVLE TFQTSSIKES TLIPPPPPLE QTFPSLQLGA
STLQRPGSQK QAGDGPALRS PPPLPVAPPA PEFPWMKEKK STKKPSQSAA SPSPAASSVR
ASEVGSPSDG PGLPECGGSG SRRLRTAYTN TQLLELEKEF HFNKYLCRPR RVEIAALLDL
TERQVKVWFQ NRRMKHKRQT QHREPPEGEP GGPSAQDDAG EPAEEPTVSP GDVATHRLRE
ACFHPAEAAQ GPRGAPPSAL PATTLESVGA SSPGCTMLRA GGRQSEPLPE DACPERQDSP
FLPDLNFFAA DSCLQMSGGL SPSLQGSLDS PVPFSEEELD FFTSTLCAID LQFP
