HXB3A_DANRE
ID HXB3A_DANRE Reviewed; 417 AA.
AC O42368; Q4VBK5; Q8AWY5;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 3.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Homeobox protein Hox-B3a;
DE Short=Hox-B3;
GN Name=hoxb3a; Synonyms=hoxb3; ORFNames=zgc:111819;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Embryo;
RA Hunter M.P., Prince V.E.;
RT "Ectopic expression of Hox paralog group 3 genes disrupts zebrafish
RT hindbrain organization and craniofacial development in the absence of
RT homeotic transformations.";
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Larva;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 208-417, AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo;
RX PubMed=9425135; DOI=10.1242/dev.125.3.393;
RA Prince V.E., Moens C.B., Kimmel C.B., Ho R.K.;
RT "Zebrafish hox genes: expression in the hindbrain region of wild-type and
RT mutants of the segmentation gene, valentino.";
RL Development 125:393-406(1998).
RN [5]
RP SEQUENCE REVISION.
RA Prince V.E.;
RL Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE STRUCTURE.
RX PubMed=15054858; DOI=10.1002/jez.b.20012;
RA Hadrys T., Prince V.E., Hunter M.P., Baker R., Rinkwitz S.;
RT "Comparative genomic analysis of vertebrate Hox3 and Hox4 genes.";
RL J. Exp. Zool. B Mol. Dev. Evol. 302:147-164(2004).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: First expressed at the 1- to 2-somite stages
CC posterior to rhombomere 5 (r5) of the developing hindbrain. By the
CC 3- to 4-somite stages, the anterior expression limit is at the r4/r5
CC boundary. At 5- to 10-somite stages, expressed at high levels in r5 and
CC r6. From the 20- to 30-somite stages, expressed weakly in r4.
CC {ECO:0000269|PubMed:9425135}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; AJ537509; CAD61096.1; -; mRNA.
DR EMBL; AL645782; CAD59116.1; -; Genomic_DNA.
DR EMBL; BC095559; AAH95559.1; -; mRNA.
DR EMBL; Y13944; CAA74282.2; -; mRNA.
DR EMBL; BK005081; DAA05213.1; -; mRNA.
DR EMBL; BK005082; DAA05214.1; -; mRNA.
DR RefSeq; NP_571192.2; NM_131117.3.
DR RefSeq; XP_005171611.1; XM_005171554.3.
DR RefSeq; XP_005171619.1; XM_005171562.3.
DR RefSeq; XP_017208627.1; XM_017353138.1.
DR RefSeq; XP_017208629.1; XM_017353140.1.
DR RefSeq; XP_017208630.1; XM_017353141.1.
DR RefSeq; XP_017208632.1; XM_017353143.1.
DR AlphaFoldDB; O42368; -.
DR SMR; O42368; -.
DR STRING; 7955.ENSDARP00000072928; -.
DR PaxDb; O42368; -.
DR Ensembl; ENSDART00000078466; ENSDARP00000072928; ENSDARG00000029263.
DR Ensembl; ENSDART00000153512; ENSDARP00000128207; ENSDARG00000029263.
DR Ensembl; ENSDART00000174580; ENSDARP00000144466; ENSDARG00000029263.
DR Ensembl; ENSDART00000182247; ENSDARP00000156821; ENSDARG00000029263.
DR Ensembl; ENSDART00000184299; ENSDARP00000155326; ENSDARG00000029263.
DR Ensembl; ENSDART00000187409; ENSDARP00000153325; ENSDARG00000029263.
DR GeneID; 30339; -.
DR KEGG; dre:30339; -.
DR CTD; 30339; -.
DR ZFIN; ZDB-GENE-990415-104; hoxb3a.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000159774; -.
DR HOGENOM; CLU_051508_1_0_1; -.
DR InParanoid; O42368; -.
DR OMA; PPLKGCA; -.
DR OrthoDB; 934469at2759; -.
DR PhylomeDB; O42368; -.
DR TreeFam; TF315938; -.
DR PRO; PR:O42368; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 3.
DR Bgee; ENSDARG00000029263; Expressed in rhombomere 6 and 41 other tissues.
DR ExpressionAtlas; O42368; baseline.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR025281; DUF4074.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF13293; DUF4074; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..417
FT /note="Homeobox protein Hox-B3a"
FT /id="PRO_0000200120"
FT DNA_BIND 180..239
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 51..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 237..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 140..145
FT /note="Antp-type hexapeptide"
FT COMPBIAS 51..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 114
FT /note="G -> V (in Ref. 3; AAH95559)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 417 AA; 44580 MW; 33A68839BE3CC35A CRC64;
MQKTTYYDNS TLFGGYSYQG ANGFGYDAPA PAFQNSAHLE GDYQRSACSL QSLGTSAPPQ
PQHAKTKELN GSCMRPSLPP EHHPPPQVSP PQNTVNVAAT NATQQPGGSG GGGGAGSGGT
SKSSSKSSSM ATNPTLTKQI FPWMKESRQN TKQKNSSPSA SSANAESSGG EKSPPGSAAS
KRARTAYTSA QLVELEKEFH FNRYLCRPRR VEMANLLNLS ERQIKIWFQN RRMKYKKDQK
SKGIGSSSGG PSPTGSPPLP MQSSAGFMNS MHSMGSYDAP SPPSFNKPHQ NAYAMSTAYQ
NPMKGCPPQQ KYGNTPPDYD PHGLQGNSGN YGTPNMQGSP VYVGGNYVDA MPATGPSMYG
LNHLPHHQSA SMDYNGATQM SANQHHGPCD PHPTYTDLSA HHPSQGRIQE APKLTHL
